Alkylating Agents - Unusual Toxicities Flashcards by Barrett Thompson | Brainscape

Q

Cylcophosphamide (Unusual Toxicity)

• agent to counter it?

A

Lung Fibrosis
renal/urotoxic (Hemmorrhagic Cystitis)
Congenital Heart Failure

• MESNA is renoprotective from acrolein

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Q

Procarbazine (Unusual Toxicity)

A

Disulfram-like effect

- weak MAO inhibition

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Q

Carmustin (BCNU) (Unusual Toxicity)

A

Hepatic “veno-occlusive”

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Q

Carboplatin (Unusual Toxicity)

• Protective agents?

A

Thrombocytopenia
Peripheral Neuropathy
less renal toxicity than Cisplatin

Amifostine in Nephroprotective

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Q

Lomustine (CCNU) (Unusual Toxicity)

A

CNS - siezures, Dementia

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Q

Mehphalan (Unusual Toxicity)

A

Lung fibrosis

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Q

Cisplatin (Unusual Toxicity)

• Protective agents

A

Renal Toxicity
Ototoxicity
Peripheral Neuropathy

Amifostine in Nephroprotective

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Q

Busulfan (Unusual Toxicity)

A

Lung Fibrosis
Addison-like syndrome
Hepatic “veno-occlusive’

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Q

Ifosfamide (Unusual Toxicity)

• Protective agents?

A

CNS toxicity
Renal/ Urotoxic (Hemorrhagic Cystitis via acrolein)

MESNA counters the effects of acrolein

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