DRUGS TO REDUCE CANCER DRUG TOXITICY

Question 1

Allopurinol, Rasburicase

- consequence

Answer 1

Given for:
- Tumor Lysis Syndrome

Consequence:

• Reduce Uric acid Level
• Renal protective

Question 2

Mesna

- consequence

Answer 2

Oncology Agent:
- Cyclophosphamide, Ifosfamide

Consequence:
- Protect against Acrolein Product

Question 3

Amifostine

- consequence

Answer 3

Oncology Agent:
- Cisplatin

Consequence:
- Cytoprotection

Question 4

Leucovorin

- consequence 1 and 2

Answer 4

Oncology Agent:

a. MTX
b. 5-FU

Consequence:

a. Metabolic Rescue
b. Enhanced Action

Question 5

Allopurinol

- consequence

Answer 5

Oncology Agent:
- 6-MP (mercaptopurine)

Consequence:
- Increases Toxicity

Question 6

Dexroxazone

- consequence

Answer 6

Oncology Agent:
- Anthrcyclines

Consequence:

• Fe Chelator
• Reduced Cardiotoxicity