Topical Antibotics Flashcards

Bacitracin, Polymixin B, Fusidic acid, Mupirocin

1
Q

Describe Bacitracin spectrum of activity for:
(G+)
(G-)

  • what is its main clinical use?
A

(G+) staph, strep, commensal skin flora.
(G-) NONE.

  • GRAM POSITIVE skin INFECTIONS –> Used for prevention and trx of minor cuts/scrapes. Often formulated with polymixin B and neomycin.
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2
Q

Describe PolymixinB spectrum of activity for:
(G+)
(G-)

  • what is its main clinical use?
A

(G+) - NONE
(G-) - covers many gram negs. retained actiivyt agaist many multidrug resistant bacilli.

clinical usse: GRAM NEGATIVE skin INFECTIONS –> prevention and trx of minor skin infections (often in combo with bacitracin and neomycin).

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3
Q

what is its main clinical use for mupirocin?

  • any gram neg coverage?
  • why shoudln’t mupirocin be used for longer than 7 days courses?
A

Main area of activity: G+ skin infections + spares skin flora BUT has increased resistance to staph.

  • has nO GRAM NEG COVERAGE.
  • cuz long term use can lead to resistance with staph.
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4
Q

What is hte main area of activity for fusidic acid ?

what are its 4 main clinical uses?

A
  • Gram positives only w/ decreased resistance to staph (only 1-2%).

1) impetigo
2) folliculitis (staph and strep)
3) decolonization of nares (staph aureus)
4) prophylaxis in catheter related and surgical site infections.

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