Topical Antibotics Flashcards
Bacitracin, Polymixin B, Fusidic acid, Mupirocin
Describe Bacitracin spectrum of activity for:
(G+)
(G-)
- what is its main clinical use?
(G+) staph, strep, commensal skin flora.
(G-) NONE.
- GRAM POSITIVE skin INFECTIONS –> Used for prevention and trx of minor cuts/scrapes. Often formulated with polymixin B and neomycin.
Describe PolymixinB spectrum of activity for:
(G+)
(G-)
- what is its main clinical use?
(G+) - NONE
(G-) - covers many gram negs. retained actiivyt agaist many multidrug resistant bacilli.
clinical usse: GRAM NEGATIVE skin INFECTIONS –> prevention and trx of minor skin infections (often in combo with bacitracin and neomycin).
what is its main clinical use for mupirocin?
- any gram neg coverage?
- why shoudln’t mupirocin be used for longer than 7 days courses?
Main area of activity: G+ skin infections + spares skin flora BUT has increased resistance to staph.
- has nO GRAM NEG COVERAGE.
- cuz long term use can lead to resistance with staph.
What is hte main area of activity for fusidic acid ?
what are its 4 main clinical uses?
- Gram positives only w/ decreased resistance to staph (only 1-2%).
1) impetigo
2) folliculitis (staph and strep)
3) decolonization of nares (staph aureus)
4) prophylaxis in catheter related and surgical site infections.