Penicillins Flashcards

1
Q

What are the 5 penicillins?

A

pen G/V, cloxacillin, Ampicillin/amox, Amox Clav, Pip Tazo

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2
Q

Describe the spectrum of Activity for PEN G/V FOR:
- GRAM POSITIVES
- GRAM NEGS
- ANAEROBES

A

Gram Pos:
- strep
- some enterococci- E. faecalis mostly.
- NO STAPH

Gram NEg: N. meningitidis, syphilis only.

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3
Q

Describe the spectrum of Activity for AMPICILLIN/AMOXICILLIN FOR:
- GRAM POSITIVES
- GRAM NEGS
- ANAEROBES

A

Gram Pos:
● Streptococci
● Some enterococci (E. faecalis mostly)
No staphylococci
● Listeria monocytogenes

Some:
o Haemophilus influenzae
o Escherichia coli
o Proteus mirabilis
NOTE: WE DO NOT TREAT GRAM NEGS EMPIRICALLY WIHT AMOXICILLIN CUZ OF INCR RESISTANCE. that’s what clav is for.

PLUS
● N. meningitidis
● Borreliella burgdorferi

{B HEP }

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4
Q

Describe the spectrum of Activity for AMOX CLAV FOR:
- GRAM POSITIVES
- GRAM NEGS
- ANAEROBES

A

Gram Pos:
As with amp/amox, plus:
o Staphylococci (MSSA)

Enhanced activity against:
● H. influenzae
● Proteus
● E. coli
● Klebsiella

PLUS
● Moraxella catarrhalis
● N. meningitidis
● B. burgdorferi

Anerobic coverage : Yes (g- anaerobes)

{MB HPEK}

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5
Q

Describe the spectrum of Activity for PIP TAZO FOR:
- GRAM POSITIVES
- GRAM NEGS
- ANAEROBES

A

Gram pos: similar to amox clav

Gram neg:
● Pseudomonas aeruginosa
● H. influenzae
● M. catarrhalis

Enhanced activity against:
● Enterobacterales {PEK}

** PIP TAZO IS BRAODEST SPECTRUM PENICILLIN.

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6
Q

DO ALL PENICILLINS COVER N. MENINGITIDIS?

A

YES!!!

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7
Q

Are the penicillins great against staph aureus?

A

no! Cephs are better (hence use in SSTIs).

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8
Q

Which two penicillins cover B. Fragilis?

A

amox clav and pip tazo only

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9
Q

Do all the penicillins cover oral anaeraobes?

A

yes!

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10
Q

Do any penicillisn cover C. diff?

A

no!!!

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11
Q

WHICH agent is the broadest spectrum penicillin?

A

pip tazo!!

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12
Q

do most penicillins need to be renally ajdusted?

A

yes!

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