Topic Lectures Flashcards
What is an iPS cell? How were iPS cells created?
How might these be used in drug design and development processes ?
What are the key features of an antibody and how have these features been exploited for development as immunotherapies?
How do current monoclonal antibody immunotherapies of autoimmune disease differ from previous treatments?
What is a monoclonal antibody ? Can you give examples of the targets and those that have been developed ?
How are monoclonal antibodies developed ?
Explain why some monoclonal antibody therapies are effective across a range of diseases?
What are the mechanisms of action of different RNA-directed and oligonucleotide therapeutics?
How do siRNA differ from miRNA?
What approach would you take in treating a disease involving RNA overexpression?
Define the components of the blood brain barrier and thus differentiate which types of compounds can readily cross this barrier.
What is an agonist/antagonist? Provide an example for each of these acting at cholinergic, adrenergic, dopaminergic, glutamatergic, GABAergic, serotoninergic and histaminergic receptors?
What is a monoamine oxidase inhibitor?
