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Epidemiology - MIDTERM 1 > Topic 8 - Circoviral disease of swine (PMWS, PDNS). > Flashcards

Topic 8 - Circoviral disease of swine (PMWS, PDNS). Flashcards

1
Q

Which family does the circovirus belong?

A

Circoviridae family

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2
Q

Shape and size of circoviridae

A

Size: 17-25 nm
Shape: icosahedral

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3
Q

Is the circovirus restistant or not?

A

VERY resistant, months in the environment

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4
Q

DNA of the circovirus:

A

Single stranded, circular.
The nucleic acid is infective making the inactivation difficult.

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5
Q

How is the replication of the circovirus?

A

Using cellular polymerase enzyme, in rapid dividing cells

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6
Q

What is the name of the circovirus in pigs, and how many types is there?

A

Porcine circovirus - PCV

4 types: PCV1, PCV2, PCV3, PCV4

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7
Q

PCV1:

A

Non-pathogenic

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8
Q

PCV2:

A

Responsible for PCV associated diseases (PCVD) or is in the
background of those

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9
Q

PCV3:

A

Its role in clinical diseases is currently unclear

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10
Q

PCV4:

A

Similar to mink circovirus

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11
Q

Which of the PCV types is the one that is most associated with the PCV?

A

PCV2

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12
Q

What is the PCV2 causative agent of?

A
  • PMWS
  • PDNS
  • PRDC
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13
Q

What is PMWS?

A

Post Weaning Multisystemic Wasting Syndrome

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14
Q

What is PDNS?

A

Porcine Dermatitis Nephropathia Syndrome

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15
Q

What is PRDC?

A

Porcine Respiratory Disease Complex

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16
Q
A
17
Q

Which other disease is caused by PCV2?

A
  1. Enteritis
  2. Epidermitis
  3. Congenital tremor
18
Q

Facts about PCV2:

A
  1. Immunosupressive
  2. Endemic
  3. The pathogen changed genetically, antigenetically, this change is continuous
19
Q

Which species is infected by PCV2?

A

Domestic pigs

20
Q

Which species is a reservoir for PCV2?

A

Wild boars and rodents

21
Q

Clinical signs of PMWS:

A
  1. Progressive weight loss
  2. Jaundice
  3. Rough hair
  4. Symptoms of co-infections
  5. fever
  6. lethargy
  7. respiratory signs
  8. nervous signs
22
Q

Which organs are especially important as a pathological search of PMWS?

A
  1. Lymphnodes
  2. lungs
  3. Thymus
  4. Heart
23
Q

Pathological signs in lymph nodes in case of PMWS:

A
  1. Enlarged
  2. Haemorrhages
24
Q

Pathological signs in lung in case of PMWS:

A

oedema, pneumonia

25
Q

Pathological signs in heart in case of PMWS:

A
  1. Flaccid myocardium
  2. ascites
26
Q

histopathological changes in case of PMWS:

A

Lymphocyte depletion
Lymph node necrosis
syntitium

27
Q

type of hypersensitivity of PDNS:

A

Type III

28
Q

Symptoms of PDNS:

A
  1. Weight loss
  2. Multifocal, circular, red skin lesions
  3. Haemorrhages, oedema
  4. Fever lethargy, anorexia
  5. Ataxia
29
Q

Differential diagnosis of PDNS:

A

Classical swine fever and african swine fever!!

30
Q

Histopathologcal signs of PDNS:

A

Exudative gomerulonephritis

31
Q

Pathological signs of PDNS:

A
  1. Enlarged brown-grayish kidney, with haemorrhages
  2. Grayish necrotic areas and haemorrhages under the kidney capsula
  3. Enlarged lymph nodes with haemorrhages
  4. Haemorrhages in skin, oedema
32
Q

Where can PCV2 be detected in a foetus and what is the main target?

A

in fetal myocardium, liver cells and macrophages

main target of the virus in the fetus is heart muscle cells

33
Q

Pathological signs in a foetus that will indicate PCV2:

A
  1. Abortus towards the end of pregnancy
  2. Dead pigs born with enlarged heart
34
Q

Which age will be targeted in case of Porcine Respiratory Disease Complex?

A

16-22 weeks of age

35
Q

Are there other agents, then PCV2, involved in case of Porcine Respiratory Disease Complex? If so, name a few:

A

Yes

– PRRSV
– Swine influenza virus
– Mycoplasma hyopneumoniae
– Actinobacillus pleuropneumoniae
– Pasteurella multocida

36
Q

How would you diagnose a pig with Porcine Respiratory Disease Complex?

A
  1. Antibiotic resistant
    respiratory diseasea
  2. Histological lesions in lungs
  3. PCV2 detected in lesions
37
Q

vaccine of PCV2

A

2 types: Inactivated, complete virus and recombinant vaccines

NO live vaccine

Both sow and piglet vaccine

38
Q

Sow vaccine for PCV2:

A

Protects from:
- Reproductive problems
- enough protection for piglet in critical age
- decrease virus load in colostrum

NO immediate effect

39
Q

Piglet vaccine for PCV2:

A

Post weaning protection

Epidemiology - MIDTERM 1 (22 decks)

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