Topic 7 Antibodies Flashcards
1
Q
Basic IgG sructure
A
2 heavy chains (4 domains ea)
2 light chains (2 Ig domains ea)
2
Q
Ig fold motif
A
beta-sandwich
3
Q
Enzyme that cleaves Ig
A
papain cleaves flexible linker
4
Q
Ig Light chain domains`
A
VL and CL
5
Q
Ig Heavy chain domains
A
VH CH1 CH2 CH3 CH4
6
Q
How many variations of V,J,C regions to choose from when making an Ig
A
300V
4J
1C
7
Q
How variable are the variable loops
A
10^8 possabilities
