Topic 6.6 - Hormones, Homeostasis, and Reproduction Flashcards
Glucagon
Secreted by: α cells in Isles of Langerhans
Function: Increases blood sugar levels in the blood
How: Turns glycogen into glucose
Insulin
Secreted by: β cells in Isles of Langerhans
Function: Lowers blood sugar levels in the blood
How: Turns glucose into glycogen
Pancreas
Maintains blood-glucose levels
Connected to the small intestine and is part of the endocrine system
Contains isles of Langerhans which contain α cells and β cells and secrete hormones (glucagon and insulin) into the bloodstream
Endocrine
Transports directly into the bloodstream
ie - Hormones
Exocrine
Transports either to a duct or out the body
ie - Salivary glands, sweat glands
Type I diabetes
Caused by: the destruction of beta cells in the isles of Langerhans (it’s an autoimmune disease). The cause of the destruction is still being researched.
Causes: inability to produce sufficient levels of insulin
Treated by: measuring blood levels and injecting insulin when necessary
Types II diabetes
Caused by: genetic factors, lack of exercise, and obesity due to consistent overeating (risk factors)
Causes: inability to respond to insulin due to insulin receptor deficiency
Treated by: Changing diet, exercising, and loss of weight
Thyroxin
Secreted by: Thyroid gland
Function: Controls metabolic rate and temperature
How: When colder, metabolic rate increases, increasing temperature
Contains: 4 atoms of iodine - iodine deficiency in the diet may cause metabolic issues
Leptin
Secreted by: Adipose tissue
Function: Controls appetite
How: More adipose tissue, more leptin produced, more leptin to bind to receptors in hypothalamus (cells in the hypothalamus control appetite), appetite decreases
Melatonin
Secreted by: Pineal gland
Function: Controls circadian rhythm
How: light is detected by the retina and the suprachiasmatic nuclei (SCN) in the hypothalamus and this inhibits melatonin production. When there is a lack of light, the inhibition stops and melatonin is secreted and stimulates sleep.
Jet lag
Caused by: crossing over 3 or more time zones - the circadian rhythm set by pineal gland and the SCN is incorrect for the current location
Causes: tiredness during the day and inability to sleep at night
Treated by: melatonin can be used / the body will eventually correct the rhythm
Sex determination in males
If the embryo has the SRY gene, it will code for a binding protein (TDF: testis determining factor) and testis will develop.
Testis normally develop by week 8
Testosterone
Causes the development of male genitalia as an embryo.
Also causes secondary characteristics to develop (deepening voice etc).
Sex determination in females
When there is a lack of the SRY gene, there is no production of testis and so the embryonic gonads develop into ovaries
During development, oestrogen and progesterone promote the development of both primary and secondary sexual characteristics
Male and female reproductive systems
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