Topic 45 - Atopy Flashcards
Atopy, definition:
Genetic predisposition to develop alleregic reaction
Most common atopy of dogs:
Atopic dermatitis
Atopic dermatitis, definition:
An inflammatory and pruritic hypersensitivity reaction to most commonly, and environmental allergen.
Can be IgE mediated or non-IgE mediated
Name the two types of atopic dermatitis, based on IgE mediated
Extrinsic = Atopy
Intrinsic = Atopic - like dermatitis
Type of reaction for atopic dermatitis
Both extrinsic and intrisinc type are Type 1 hypersensitivity
Which species is more prone to atopic dermatitis?
Dogs.
Some breeds might be predisposed
Rare in cats
Which breeds are predisposed to atopic dermatitis?
West Highland White terrier
French bulldog
Labrador
German sheperd
Golden retriever
English bulldog
Dalmatian
Poodle
Boxer
At which age is it common to develop clinical signs in case of atopic dermatitis?
Between 1-3 years of age
75% show clinical signs before 3 years of age
Clinical signs of atopic dermatitis often have triggers, what are they?
Can be seasonal or non-seasonal
Non-seasoal:
Dustmites
Moulds
Feathers
Seasonal:
Pollen
Clinical signs of atopic dermatitis:
- Pruritus is the main complaint
- Erythema: pyoderma, seborrhea, lichenification
Name the resent “criteria” for explaining atopic dermatitis:
Criteria of favrot et al
IMPORTANT!
What is the steps of Criteria of favrot et al?
- The onset of clinical signs is withing the first 3 years of life
- Puritus at onset
- Animal living indoors
- Glucocorticoid-responsive pruritus
- Affected front feet
- Affected ear pinnae
- Non-affected ear margins
- Non-affected dorso-lumbar area
If an animal show at least 5 combinations of Criteria of favrot et al, what does it mean?
85% sensitivity
79% specificity
Which tests would you do to diagnose atopic dermatitis?
Allergen tests
Such as: Intradermal skin testing, IgE test
Treatment for atopic dermatitis:
Acute: Prednisolone, oclatininb, lokivetmab
Chronic: Cyclosporine
Can also use: anti-allergy shampoo and anti-histamines
What is the aim of treatment in the case of atopic dermatitis?
- Identify and eliminate the factors causing the allergic reaction
- Improvement of the skin and coat
- Reduce the pruritus
- Reduce skin lesions
