TOPIC 4 - depressive disorders Flashcards

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1
Q

comorbidity and risk factors

A

prior history ox depression or family history
member of vulnerable groups
female
age 40 or under
active substance use
history of sexual abuse
postpartum period
stressful life events
history of other chronic mental or medical illness

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2
Q

DMDD is only diagnosed …

A

in childhood (before age 10)

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3
Q

percent of children less than 3 who have depression

A

15% (often under diagnosed and has a high recurrence rate)

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4
Q

percent of older adults with depression

A

20%

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5
Q

manifestations of depression

A

sadness, despair, empty, negative, pessimistic, anhedonia, anergia, avolition, low self esteem, apathy, social with-drawl, excessive emotional sensitivity, low frustration, irritable, insomnia, disrupted concentration, excessive guilt, indecisiveness

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6
Q

avolition

A
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7
Q

anhedonia

A
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8
Q

anergia

A
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9
Q

most common presentation of depressive symptoms in children

A

irritable (less likely to be sad or withdrawn)

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10
Q

assessing for depression

A

MSE
psychosocial assessment
physical assessment
standardized scales (Hamilton or SAD PERSONS)

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11
Q

assessing suicide risk

A

SADPERSONAS scale
SAFE-T

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12
Q

different types of suicidality

A

suicidal ideation, suicide attempt, completed suicide, parasuicidal behavior

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13
Q

monitoring and documentation guidelines for suicidal risk

A

1:1 continuous monitoring
document every 15 minutes (observations, statements, activities, behaviors)

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14
Q

biopsychosocial model

A

social / biological / psychological factors are all interlinked and important for regarding and promoting health

mind and body are not separate

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15
Q

biological factors

A

endocrine, immune, and neurosystem functioning

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16
Q

stress diathesis model

A

diathesis - predisposing cause or underlying vulnerability
stress - precipitating cause or triggering circumstance
= disorder

accounts for relationship between early life trauma and later development of vulnerability

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17
Q

cognitive theory triad

A

negative view of self + pessimistic view of world + belief that negative reinforcement will continue

people acquire a psychological disposition to depression from early life experiences

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18
Q

learned helplessness

A

condition of a human or animal that has learned to behave helplessly, failing to respond even though there are opportunities for help

(initial response to event is anxiety but then is replaced by depression- believed they are at fault)

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19
Q

depressive disorders

A

major depressive disorder
persistent depressive disorder
disruptive mood dysregulation disorder

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20
Q

major depressive disorder

A

depressed most of the day, most days of the week

significant distress or impairment in functioning due to symptoms

not attributable to substance use or other medical condition

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21
Q

persistent depressive disorder

A

chronic depression
less severe symptoms than in MDD
symptoms must have persisted for at least 2 years
able to function in life roles greater than those with MDD

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22
Q

DMDD (disruptive mood dysregulation disorder)

A

onset before age 10

s/s : severe temper outburst, inconsistent developmental level persistent irritability or anger

treatment: family supportive therapy, behavioral modification therapy, meds (stimulant, antidepressant, mood stabilizer)

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23
Q

therapy models

A

CBT, MBCT, ITP, bright light

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24
Q

MBCT

A

combination of CBT and mindfulness based stress reduction

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25
Q

bright light therapy

A

helpful for those experiencing seasonal affect disorder
light substitutes for lack of daylight in the winter months = less sleepy, more energy

26
Q

vagus nerve simulation

A

invasive procedure - implant electrodes and pulse generator that stimulates vagus nerve

approved for people with chronic or recurrent TRD who have failed to respond to four or more adequate treatments

27
Q

rapid transcranial magnetic stimulation

A

noninvasive - magnetic fields stimulate nerve cells in the brain to improve symptoms of depression

28
Q

deep brain stimulation

A

for movement disorders such as tremors, parkinsons, or OCD

29
Q

noninvasive modes of brain stimulation vs invasive

A

non invasive = TMS or rTMS and ECT
invasive = VNS, deep brain stimulation

30
Q

indications for ECT

A

patient is suicidal or homicidal, extreme agitation, life threatening illness as a result of the refusal of nutrition, history of poor antidepressant drug response

31
Q

side effects of ECT

A

nausea, dizzy, short term memory loss, weakness (procedure elicits a seizure)

32
Q

first line antidepressants

A

SSRI
SNRI
atypical antidepressants
TCAs

33
Q

atypical antidepressants

A

mirtazapine
bupropion
ketamine & esketamine

34
Q

second line antidepressants

A

MAOIs
CAMs

35
Q

FDA requires what on all antidepressant meds

A

black box warning

36
Q

SSRI meds

A

fluoxetine
fluvoxamine
paroxetine
citalopram
escitalopram
sertraline

37
Q

side effects of SSRI

A

headache, nausea, sexual problems

serotonin syndrome

38
Q

onset and effectiveness of SSRI

A

Onset of effectiveness: 1-2 weeks (varies by drug)
Full effectiveness: 2-4 weeks (varies by drug)

39
Q

decrease dose if …

A

side effects are intolerable but the medication has been effective for lessening symptoms

40
Q

client teaching for SSRIs

A

allow time for symptom relief
report intolerable side effects or worsening depression
risk for suicide in first 1-4 weeks

41
Q

half life of fluoxetine

A

5 weeks

42
Q

how long to wait between fluoxetine and starting other meds

A

If changing from fluoxetine to an MAOI, the client must wait 5 weeks to begin the MAOI to avoid serotonin syndrome
If changing from a different SSRI to an MAOI, the wait between meds must be 2 weeks; also 2 weeks if switching from an MAOI to an SSRI (including fluoxetine)

43
Q

clinical presentation of serotonin syndrome

A

Hyperactivity or restlessness
Tachycardia _ cardiovascular shock, irregular heartbeat
Fever _ hyperpyrexia
Elevated blood pressure
Irrationality, mood swings, hostility
Altered mental status (e.g., delirium)
Seizures (status epilepticus)
Myoclonus, incoordination, tonic rigidity
Abdominal pain, diarrhea, bloating
Apnea (may lead to death)

44
Q

treatment of serotonin syndrome

A

Administer serotonin receptor blockade (cyproheptadine, methysergide, propranolol)

Cooling blankets, chlorpromazine (for hyperthermia)

Dantrolene, diazepam (for muscle rigidity or rigors)

Anticonvulsants

Artificial ventilation

Induced paralysis

45
Q

labs to assess evaluation of serotonin syndrome

A
  • complete blood count (CBC)
  • blood culture
  • thyroid function tests
  • drug screens
  • kidney function tests
  • liver function tests
46
Q

onset of effectiveness for SNRIs

A

2-4 weeks

47
Q

side effects of SNRI

A

Nausea, dizziness, nervousness, anticholinergic effects
Increase in blood pressure
Titrate on/ taper off and use extended release to decrease side effects, do not discontinue abruptly
serotonin syndrome

48
Q

client teaching for SNRI

A

allow time for symptom relief, report intolerable side effects, titration of drug dose, monitor for suicidality, DON’T STOP ABRUPTLY

49
Q

contraindications for SNRI

A

HTN and glaucoma

50
Q

mirtazapine (tetracyclic antidepressant)

A

Good for elderly & those with severe depression
Less insomnia SE, less sexual dysfunction SE
COMMON SIDE EFFECTS (SE):
Significant weight gain
Sedation

51
Q

bupropion (NE dopamine reuptake inhibitor)

A

Little effect on weight or sexual function
Also marketed for smoking cessation (discussed further in Topic 10)
COMMON SIDE EFFECTS (SE):
Energizing (possible increased anxiety, insomnia; risk for mania induction in clients with undiagnosed bipolar disorder)

52
Q

NMDA antagonists

A

ketamine and esketamine

for severe treatment of resistant depression

53
Q

admin of NMDA antagonists

A

nasal spray - esketamine
inject - ketamine

admin 1-2 times a week in the providers office

54
Q

TCAs

A

dose titration
onset of effectiveness : 10-14 days
full effectiveness : 4-8 weeks
side effects : postural hypotension, tachycardia. urinary retention, constipation, serotonin syndrome

55
Q

TCA dosages

A

start low go slow

56
Q

client teaching for TCAs

A

take at bedtime
fall precautions
do not stop abruptly

57
Q

contraindications for TCAs

A

MANY drug-drug interactions!
Recent MI
Narrow-angle glaucoma
History of seizures
Pregnant women

58
Q

MAOI side effects

A

Hypotension
Muscle cramps
Sedation, weakness, fatigue OR insomnia
Anorgasmia or sexual impotence
Weight gain
Anticholinergic effects
Hypertensive crisis

59
Q

avoid which foods and drugs while on MAOIs

A

tyramine foods

OTC meds, other antidepressants, narcotics, general anesthetics, stimulants, sedatives

60
Q

2 week med break needed for MAOIs when …

A

between taking MAOI and ingesting any food, drink, or product containing tyramine

when switching from MAOI to or from another antidepressant

5 weeks needed for switches between fluoxetine and MAOIs

61
Q

hypertensive crisis

A

excessive tyramine = can lead to CVA

s/s : headache, stiff neck, tachycardia, severe nosebleeds, dilated pupils, chest pain, stroke, N/V/D

62
Q

ER admin of meds for hypertensive crisis

A

if BP elevated

IV phentolamine
oral chlorpromazine
sublingual nifedipine