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Tooth Development Flashcards

1
Q

What are the growth factors responsible for the shape of tooth?

A

SHH, FGFs, BMPs, and WNT

*and MSX2 (transcription factor)

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2
Q

extra enamel know express?

A

Fgf4

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3
Q

enamel organ is supported by?

A

basal lamina

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4
Q

outer enamel organ contents

A
  • low cuboidal & high nuclear/cytoplasmic ratio
  • free ribosomes, rER, mitochondria
  • *few scattered TONOFILAMENTS
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5
Q

stellate reticulum are connected to?

**shape?

A

1) each other
2) OUTER enamel epithelim
3) stratum intermedium via desmosomes
* **STAR SHAPED

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6
Q

stratum intermedium connected to?

A

1) each other
2) INNER enamel epithelim
3) stellate reticulum via desmosomes

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7
Q

inner enamel epithelium contents?

A
  • central nucleus
  • *high glycogen content
  • *poorly devel Gogli
  • free ribosomes, rER, mitochondria, some TONOFILAMENTS
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8
Q

enamel organ derived from?

A

oral epithillum via dental lamina

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9
Q

enamel organ determines?

A

shape of crown

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10
Q

enamel organ induced the formation of?

A

dentin

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11
Q

enamel organ establishes the _____ juntion?

A

dentogingival

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12
Q

enamel organ FORMS?

A

enamel of tooth

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13
Q

Stellate reticulum cells secrete? what does this do?

A

Glycosaminoglycans (GAGs)

**GAGs draw water into enamel organ increasing its volume

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14
Q

Stratum intermedium adjacent to?

ssential for?

A
  • adjacent to inner enamel epithelium
  • Essential for enamel formation and mineralization – alkaline phosphatase!!!!
  • *MUST be present or ameloblasts will not secret enamel
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15
Q

Inner enamel epithelium (IEE) differentiates into?

A

ameloblasts (enamel forming cells)

*Initiate dentin formation

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16
Q

during cap stage IEE/ameloblasts forms the?

A

enamel knot

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17
Q

what is hertwigs sheath?

A

place of contact between outer and inner enamel epithelium

*define the SHAPE and FORMATION OF THE ROOT

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18
Q

dentinogenesis

A

odontoblasts produce dentine toward inner ameloblasts

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19
Q

amelogenesis

A

inner ameloblasts produce organis substance of enamel against the dentine, formation of the crown

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20
Q

ameloblasts ____ off the layer of enamel

A

retreat off!!

21
Q

the permenet dentition arises from?

A

dental lamina

22
Q

The tooth germs that give rise to the permanent incisors, canines, and premolars form as a result of further proliferative activity within the??

A

dental lamina at its deepest extremity

23
Q

increased proliferative activity at the dental lamina’s deepest extremity leads to?

A

formation of another tooth bud (permanent) on the lingual aspect of the deciduous tooth germ

24
Q

do the molars of permanent dentition originate the same way as incisors, canines, and premolars?

A

NO! Bc they have no deciduous predecessors

25
When the jaws have grown long enough, the dental lamina burrows posterioly? WHY?
posteriorly beneath the lining epithelium of the oral mucosa into the ectomesenchyme **This backward extension gives off epithelial outgrowths that, with associated ectomesenchymal response, form the tooth germs of the 1, 2, and 3rd molars
26
the primary epithelial band divides into? *** which one forms first?
1) outer thicker VESTIBULAR LAMINA that is repsonsible for separation of lips/cheeck (**forms second and is in front if DL) 2) inner smaller DENTAL LAMINA which gives rise to teeth!!!
27
asdental lamina grows in length, its penetrates deeper into the?
mesenchyme * at front of mouth= shelf like * back= more vertical
28
mesenchymal tissue surrounding the developing enamel gives rise to?
dental lamina (primitive pulp) and follicular sac for each tooth bud
29
What is the tooth germ?
the combination of enamel organ, dental papilla, and follicular sac *ALL THREE
30
enamel organ in bud stage
* simple, spherical | * poorly morpho and histo differentiated
31
bud stage becomes concave on what side?
papillary surface/side
32
primary knot determines?
the position of the secondary enamel knots corresponding to the site of future CUSPS
33
what is the enamel cord? | **thought to be involved in what two events?
strand of cells seen at early bell stage * it overlies the incial margin of a tooth or the apex of the first cusp to develop * ***thought to be involved in cap to bell process OR the focus for the origin of stellate reticulum cells
34
are permanent molars regarded as part of deciduous series?
Yes, but they arise so differently that it is questioned if that is true
35
what is the cervical loop?
where the inner and outer layers of the bell stage curve and MEET **the ACTIVE SITE of cellular proliferation until the ENTIRE TOOTH is mapped out
36
the vestibular lamina band growth occurs
at the same time as dental lamina | *around CAP stage the vertical cleft establishes vertical band and thus separates lips
37
what is Pax9?
one of the earliest mesenchymal genes that define the localization of the tooth germs *expressed at bud stage mesenchyme
38
Pax9 induced by?
Fgf-8 which has some tooth positioning role (represented by bone morphogenetic proteins BMP-2 and BMP-4)
39
Fgf-8, Bmp-2, and Bmp-4 are expressed in? | Pax9 expressed in?
non-overlapping areas | *Pax9 is expressed at sites where Fgf-8 but not BMPs are
40
What if you have no Msx genes?
may have no premolars
41
3 stages of tooth develoment?
bud, cap, bell | AND THEN crown stage (dentinogenesis and amelogenesis), root formation, tooth eruption
42
1) Histodifferentiation 2) initiation 3) Morphogenesis
1) differentiation of primitive cells into tooth germ population 2) site of future teeth established 3) shape of the tooth determined
43
Is the epithelium or the mesenchyme responsible for tooth morphology?
``` early= epithelium directs patterning late= mesenchyme directs patterning (Reciprocal Signaling) ```
44
dental papilla
* undifferenciated mesenchyma cells | * MAKES PULP
45
dental follicle
* MAKE CEMENTUM AND ROOT | * distinguishable from dental papilla bc it has many more collagen fibrils
46
ameloblastoma
is an EXAMPLE of the severel types of odontogenic cysts/tumors that can arise from developing tooth structures (like epithelium, cell rests, enamel organ)
47
blood enters dental papilla during what stage?
cap * the # of vessels increases until the bell stage when matrix is deposited * enamel organ is avascular but has vessels ajacent to OEE * vessels cluster in groups in papilla where the ROOTS will form
48
nerve fibers approach developing tooth during? when do they penetrate? nerve growthfactors?
bud to cap stage * pentrate pulp when dentinogenesis begins * neurotrophin, glial cell line derived growth factor, semaphorin

Embryology (12 decks)

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