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Oral Biology II > Tooth Development > Flashcards

Tooth Development Flashcards

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1
Q

What guides organogenesis?

A

Epithelial-mesenchymal interactions

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2
Q

What are the 4 types of cell communication?

A

1-Autocrine (cell on itself)
2-Paracrine (Cell on another near by)
3-Endocrine (carried by blood stream)
4-Intracrine (acts inside the cell rather than on receptors)

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3
Q

Migration of Neural crest cells to where is important for development of oral tissues?

A

1st arch

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4
Q

Ectomesenchyme (neural crest) is responsible for what parts of the dentition?

A
  • Dentin
  • Bone
  • Cementum
  • Periodontal ligament
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5
Q

What thickened band of cells early in development eventually give rise to teeth?

A

Dental lamina

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6
Q

An early bud off (successional dental lamina) of the larger forming tooth bud is likely to be what?

A

Succedaneous tooth (permanent tooth)

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7
Q

What are the 6 stages of Crown development?

A

1-Initiation (induction)
2-Bud stage (proliferation)
3-Cap stage (proliferation, differentiation, morphogenesis)
4-Bell stage (proliferation, differentiation, morphogenesis)
5-Apposition stage (induction and proliferation)
6-Maturation stage

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8
Q

The process whereby one tissue changes the development of surrounding tissues is called what?

A

induction

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9
Q

The inner area of the tooth germ is called what?

A

enamel organ

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10
Q

the condensed ectomesenchyme oaround the developing cap of the tooth germ is called what?

A

dental papilla

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11
Q

The location of differential genes where expression begins is called what?

A

the enamel knot

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12
Q

What are the four layers of the bell stage?

A

1-outer enamel epithelium (protects enamel organ)
2-stellate reticulum (star shaped, support enamel production)
3-stratum intermedium (separates layers, supports enamel mineralization)
4-inner enamel epithelium (becomes ameloblasts)

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13
Q

The junction of the outer and internal enamel epithelium is called what?

A

Cervical loop

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14
Q

What stimulates the pre-dental ectoderm to produce Fgf-8?

A

Lef-1

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15
Q

What induces the underlying mesenchyme to express Pax-9 and Msx-1 beneath the thickened dental lamina?

A

Fgf-8

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16
Q

What inhibits Fgf-8?

A

BMP-2 and 4

17
Q

The dental sac later develops into what?

A

Periodontal tissue

18
Q

The stage during which organic matrix of enamel and dentin are laid down is called what?

A

Appositional stage

19
Q

What is the order of reciprocal induction?

A
  • Inner Enamel Epithelial cells differentiate into pre-ameloblasts and become polarized
  • Preameloblasts then include outer dental papilla cells to differentiate into preodontoblasts which turn into odontoblasts
20
Q

Preameloblasts start producing enamel when then see what , produced by odontoblasts?

A

Predentin

21
Q

What is formed once the basement membrane disintegrates?

A

Dentinoenamel junction (DEJ)

22
Q

Tomes processes of late secretory ameloblasts form what?

A

Enamel prisms (prismless enamel is formed by early secretory ameloblasts)

23
Q

Enamel matrix secreted by Ameloblasts immediately calcify to ______% of full mineralization

A

25%

24
Q

What are the seven stages of ameloblast life cycle

A

1-Inner enamel epithelial cells
2-Preameloblasts (reverse polarity)
3-Initial secretory ameloblast (prismless enamel)
4-Secretory ameloblast (Tomes process/enamel process)
5-Smooth-ended maturation ameloblast (remove protein/water)
6-Ruffled-ended maturation ameloblast (introduction of inorganic material)
7-Protective ameloblast (enamel cuticle)

25
Q

Once the enamel has fully matured what forms?

A

Reduced enamel epithelium (REE)

26
Q

initial dentin mineralization is in the form of globules and produces what?

A

globular dentin

27
Q

Initial layers of dentin next to the DEJ is called what?

A

Mantle dentin (Perpendicular fibers)

28
Q

Dentin around the pulp is called what?

A

Cirumpulpal dentin (parallel fibers)

29
Q

What has odontoblasts inside and cementoblasts outside and induces root formation?

A

Hertwigs Epithelial Root Sheath (HERS)

30
Q

Hertwigs Epithelium Root sheath remnants that persist in the Periodontal ligament are called what?

A

Epithelial rests of Malassez

31
Q

Induction of dental sac cells differentiate into what?

A

Cementoblasts which secrete cementoid which mineralizes into cementum

*if cemtoblasts are trapped into lacunae they are cemtocytes

32
Q

Dental sac ectomesenchyme cells differentiate into what?

A

Fibroblasts that secret collagen and form the PDL

Oral Biology II (13 decks)

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