Repair and Regeneration Flashcards
Complete restoration of tissue architecture and function is called?
Regeneration (good as new)
Restoration of function but altered architecture is called?
Repair (scars)
What are the 4 general phases of tissue repair?
1-Hemostasis (Clot formation)
2-Inflammatory (infiltration of immune cells)
3-Reparative phase (proliferative, migration of cells)
4-Wound contraction and scarring
Exposure of collagen in sub endothelium to circulating von willebrand factor causing platelet aggregation is typical of what stage of hemostasis?
Primary hemostasis (platelet plug)
*Secondary Hemostasis (blood coagulation) happens simultaneously or just after
What are the two pathways of Secondary hemostasis?
- Extrinsic (factor VII and tissue factor interaction)
- Intrinsic (initiated by damaged endothelium (collagen exposure))
What do both extrinsic and intrinsic pathways of blood coagulation eventually activate?
Fibrinogen (soluble) to fibrin (insoluble)
*Prothrombin converts to thrombin to do this
What happens during the reparative/proliferation phase?
Cells migrate under fibrin clot and proliferate forming new hemidesmosomes and collagen scaffold. Angiogenesis also takes place
What cells work to draw wound edges together?
Myofibroblasts (increased actin/myosin)
Why is there no scar formed in periodontal repair?
Immediate remodeling of collagen by ligament fibroblasts
*important for tooth movement. GF are added or membranes used to encourage ligament reattachment and limit epithelial invasion
What are the 3 primary zones (outer to inner) for dental caries?
1-Surface and body (surface zone re-mineralizes, body is primary zone of demineralization)
2-Dark zone (zone of increasing demineralization)
3-Translucent zone (leading edge of caries)
Dentin formed between surviving dentin and restorative material preventing micro leakage is called what?
Dentin bridge
