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BMS3052 > Tolerance and Autoimmunity > Flashcards

Tolerance and Autoimmunity Flashcards

1
Q

Describe the roles of T and B cells and antibodies in SLE.

A

T cells: pathogenic, help for antibody
B cells: present antigen to T cells
Antibodies: pathogenic

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2
Q

Describe the roles of T and B cells and antibodies in type I diabetes.

A

T cells: pathogenic
B cells: present antigen to T cells
Antibody: unclear, present

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3
Q

Describe the roles of T and B cells and antibodies in Myasthenia gravis.

A

T cell: help for antibody
B cells: antibody secretion
Antibody: pathogenic

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4
Q

Describe the roles of T and B cells and antibodies in MS.

A

T cell: pathogenic
B cells: present antigen to T cells
Antibody: unclear, present.

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5
Q

In which organs in the Type IV collagen non-collagenous domain found?

A

Kidney, lung, testis, neuromuscular junction, choroidal plexus.

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6
Q

List the clinical features of SLE

A

Skin disease, GN, autoantibodies to nuclear proteins, anaemia, reduces platelets/WBCs, joint disease, pleurisy, cerebritis/psychosis

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7
Q

What signalling molecules to Treg cells express?

A

CD4+, CD25 (growth factor for IL-2 receptor alpha), Foxp3 (lineage specific factor)
Some express IL-10 and TGF-beta

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8
Q

Which cytokine can immature DCS use to induce Tregs?

A

TGF-beta

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9
Q

What are the fate-specifying cytokines for TH1 cells?

A

IFN-gamma, IL-12

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10
Q

What are the fate-specifying cytokines for TH2 cells?

A

IL-4

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11
Q

What cytokine do Th-1 cells secrete?

A

IFN-gamma

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12
Q

Which cytokines do Th2 cells secrete?

A

IL-4, IL-5, IL-13

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13
Q

What are the fate-specifying cytokines for TH17 cells?

A

TGF-beta, IL-6, IL-23

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14
Q

What are the fate-specifying cytokines for Tfh cells?

A

IL-6

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15
Q

What are the fate-specifying cytokines for Treg cells?

A

TGF-beta, IL-2

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16
Q

Which cytokines do Th17 cells secrete?

A

IL-17, IL-22

17
Q

Which cytokines do Tfh cells secrete?

A

IL-21

18
Q

Which cytokines do iTreg cells secrete?

A

TGF-beta, IL-10

19
Q

Which DR allele is protective against Goodpasture’s syndrome?

A

DR-1, generate Treg cells in the thymus

DR-7

20
Q

Which DR allele confers susceptibility to Goodpasture’s syndrome?

A

DR15, more naive effector T cells produced

21
Q

Which signal is inhibitory of co-stimulation?

A

CTLA4

22
Q

What is FORp3?

A

Transcription factor in Treg cells

23
Q

Which disease do mice with IL-10 deficiency develop?

A

Inflammatory bowel disease through loss of normal regulation of gut immunity

24
Q

Mutations in which gene may lead to loss of central tolerance?

A

AIRE

25
Q

Mutations in which gene may lead to loss of peripheral tolerance?

A

Foxp3, Treg failure

26
Q

Mutations in which gene may lead to antigen clearance and presentation abnormalitie?

A

C1q

27
Q

Mutations in which gene may lead to loss of apoptosis?

A

Fas

BMS3052 (6 decks)

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