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BMS3052 > Cancer Epidemiology > Flashcards

Cancer Epidemiology Flashcards

1
Q

What percentage of cancers are due to inherited mutations?

A

5-10%

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2
Q

Give two examples of inherited cancers

A

Familial breast/ovarian cancers BRCA 1/2

Hereditary colon cancer

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3
Q

What are the mutations that lead to sporadic colorectal cancer?

A 
5q loss APC
DNA-demethylation
12p activation K-ras
18q loss DCC
17p loss p53
Other
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4
Q

What percentage of cancer is attributed to poor lifestyle?

A

1/3

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5
Q

What are the incidence and mortality for lung cancer in men like?

A

Both are high

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6
Q

What are the incidence and mortality for prostate cancer in men like?

A

High incidence, lower mortality

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7
Q

What are the incidence and mortality for breast cancer in women like?

A

High incidence, lower mortality

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8
Q

Which two cancers have the highest incidence?

A

Lung and breast

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9
Q

Which three cancers have the second highest incidence each (in order from highest to lowest)?

A

Bowel, prostate, stomach

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10
Q

Compare years of life lost (YLL) to mortality in breast cancer .

A

The years of life lost are greater as often young women are killed.

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11
Q

What percentage of cancers is attributed to smoking?

A

22%

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12
Q

What percentage of cancers in less developed countries is attributed to specific infections?

A

23.4%

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13
Q

What percentage of cancers in developed countries is attributed to specific infections?

A

7.5%

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14
Q

What parameters need to be known to determine the attributable burden?

A

Past prevalence of population exposure to risk

Relative risk of association with a cancer disease

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15
Q

What percentage of mouth and oropharynx cancers in med are attributable to alcohol?

A

22%

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16
Q

What percentage of breast and colorectal cancer mortalities is attributable to a high BMI, respectively?

A

19%

26%

17
Q

What percentage of breast cancer is attributable to high BMI?

A

40%

18
Q

What percentage of hepatocellular carcinoma is attributed to HBV and HCV, respectively?

A

50%

20%

19
Q

What cancers are caused by HPV?

A

90% of anal cancer
40% of external genitalia cancer
All cervical cancers

20
Q

To what percentage of cancer does pollution attribute to?

A

1-4%

21
Q

What percentage of cancers is preventable?

A

30-40%

22
Q

How many deaths each year are attributed to alcohol?

A

3.3 million. 5.9%

23
Q

When is the HBV vaccine first received?

A

Neonates

24
Q

What portion of breast cancer risks are modifiable?

A

2/3

25
Q

What PAF% does smoking contribute to, in terms of lung cancer?

A

81%

BMS3052 (6 decks)

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