Tolerance And Autoimmunity Flashcards
absence of specific immune response against some
antigens in an otherwise immunocompetent person
Tolerance
T/F: Auto tolerance is natural
True
T/F: Acquired tolerance can be used to treat autoimmune
diseases, allergy & graft rejection.
True
Location of colonal deletion
In central lymphoid organs
T/F: Immature T cells that recognize self antigen die through apoptosis ( negative selection).
False
- Immature T cells that recognize self peptide plus self MHC at
high affinity die through apoptosis ( negative selection).
How are self reactive B cells controlled In peripheral tissue ?
Lack of help from T cells (th)
How are self reactive T cells controlled in the peripheral tissue ?
Lack of co-stimulation = anergy
Breakdown of auto tolerance causes
Auto immune disease
Class II MHC are normally expressed ONLY on :
APC
What increases the expression of MHC II on a variety of cells ?
IFN-gamma
M-protein of some strains of Streptococcus pyogenes
share epitopes with
The heart muscle antigens
Cross reactivity against streptococcus pyrogens can cause what diseases ?
Rheumatic fever and rheumatic heart disease
Microbe that causes polyclonal activation of lymphocytes :
Epstein Barr virus (EBV)
Probable cause for the genetic factor in autoimmune diseases ?
particular
MHC (HLA) types ,
MHC type responsible for SLE
DR3
MHC type responsible for rheumatoid arthritis
DR4
T/F: women are more likely to develop autoimmune diseases
True
Hormonal factor affecting the likeness of autoimmune diseases
Oestrogen
Graves diseases is an example if non organs specific autoimmune disease
False organ specific
