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MSK Quiz 1 > Immunology Hypersensitivity > Flashcards

Immunology Hypersensitivity Flashcards

1
Q

Which of the following doesn’t describe hypersensitivity?
A) exaggerated immune responses to harmless environmental antigens
B) exaggerated immune responses to infections
C) inappropriate immune response to auto-antigens
D) appropriate response to an antigen

A

D

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2
Q

What type is cytolytic hypersensitivity?

A

Type 2

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3
Q

What type is anaphylactic hypersensitivity?

A

Type 1

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4
Q

What type is immune-complex mediated hypersensitivity?

A

Type 3

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5
Q

What type is delayed hypersensitivity?

A

Type 4

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6
Q

What type is cell mediated hypersensitivity?

A

Type 4

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7
Q

What type is immediate hypersensitivity?

A

Type 1

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8
Q

Penicillin allergy is what type

A

1

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9
Q

What antibody mediates type 1?

A

IgE

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10
Q

Cells of type 1

A

Mast cells and eosinophils

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11
Q

——————— is when a patient forms large amounts of IgE to certain harmless antigens instead of forming a low amount ?

A

Sensitisation type 1

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12
Q

What kind of receptor do IgE molecules bind to ?

A

fC receptors

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13
Q

T/F: 1st exposure to an allergen = sensitization of Mast cells & Basophils

A

True

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14
Q

What occurs in the re exposure stage of type 1 ?

A

Antigen binds 2 adjacent IgE molecules on
mast cells (cross-linking)

Degranulation of mast cells
release granules and mediators

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15
Q

Describe Preformed mediators:

A

Histamine and platelet activating factor (PAF) ◦
Responsible for symptoms seen during the Early phase, (within 15-20 minutes of exposure to the allergen).

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16
Q

Describe Newly formed mediators:

A

leukotrienes and prostaglandins, take several hours to be synthesized, typically occurs 5-6 hours after allergen contact symptoms seen during the Late phase are the same as those of the early phase, but persist longer.

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17
Q

T/F: late phase can lead to tissue damage due to hydrolytic enzymes

A

False late phase

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18
Q

Which of the following is a symptom of systemic anaphylaxis
A) urticaria
B)conjunctivitis
C) bronchoconstriction
D) Bronchial asthma

A

C

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19
Q

T/F: Systemic anaphylaxis occurs on sensitisation to a harmless antigen ie insect venom

A

False occurs on re exposure

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20
Q

How to diagnose type 1 ?

A
  • skin test
  • measurement of serum levels
21
Q

First line of management of type 1 (excluding anaphylactic shock) ?

A

Avoidance

22
Q

Type 2 hypersensitivity antibodies ?

A

IgG and IgM

23
Q

Type of Hypersensitivity that reacts to cell bound antigens ?

A

Type 2

24
Q

ADCC is a mechanism of which type ?

A

2

25
Q

Complement activation is a mechanism of which type ?

A

2

26
Q

Opsonisation of target cell is a mechanism of which type ?

A

2

27
Q

Altered signalling is a mechanism of which type of hypersensitivity?

A

Type 2

28
Q

Transfusion reactions are examples of which type of hypersensitivity

A

2

29
Q

Hemolytic disease of the newborn is an example of which type of hypersensitivity?

A

Type 2

30
Q

Drug reactions are which type of hypersensitivity

A

Type 2

31
Q

Autoimmune hemolytic anemia
Type

A

2

32
Q

Graves’ disease is which type

A

2

33
Q

T/F: small insoluble immune complexes may escape phagocytosis

A

Soluble

34
Q

Escaped immune complexes are usually found in :

A

Sites of turbulence like joints and kidneys

35
Q

Post-streptococcal glomerulonephritis is an example of

A

Type 3

36
Q

Systemic lupus erythematosis is a what type

A

3

37
Q

Which if the following is not a diagnostic mechanism for type 3 hypersensitivity?
A) tissue biopsies for deposits of Ig and complement by immunofluorescence.
B)depleted immune complexes in serum
C) detection of immune complexes in serum
D) depleted serum complement

A

B

38
Q

Which type of hypersensitivity is not antibody mediated ?

A

Type 4

39
Q

Main cell in type 4 hypersensitivity?

A

Th1

40
Q

Which type of hypersensitivity requires previous exposure ?

A

All

41
Q

What Th1 sectretion causes the activation of macrophages?

A

IFN-γ

42
Q

Tuberculin skin test (TST) is type

A

4

43
Q

T/F:A positive reaction to the Tuberculin skin test is erythema of the area

A

Induration not erythema

44
Q

Granulation is what type?

A

4

45
Q

Contact dermatitis is what type ?

A

4

46
Q

Skin patch test is for what disease?

A

Contact dermatitis

47
Q

Skin test is for what disease ?

A

Type one hypersensitivity

48
Q

Insulin dependent diabetes type

A

4

MSK Quiz 1 (9 decks)

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