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MSK Quiz 1 > Resting Membrane Physiology > Flashcards

Resting Membrane Physiology Flashcards

1
Q

the difference in concentration of a charged
particle between one point and another.

A

electrical potential (EP)

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2
Q

charged particles flow from
one place to another through ion channels or membranes.

A

Current flow

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3
Q

In other cells like
glands, macrophages and ciliated cells local changes in membrane
potential (MP) to

A

activate many of the cell functions.

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4
Q

In nerve and
muscle cells rapidly changing electrochemical impulses which are used to

A

transmit signals

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5
Q

Production of graded potential and action potential depends on :

A
  1. Presence of specific ion channels
  2. Resting membrane potential
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6
Q

Selectivity is based on

A
  1. The charge lining the channel
  2. Size of the channel
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7
Q

Channels that are always open :

A

Leaky channels

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8
Q

Gates controlled by changes in membrane potential

A

.Voltage-gated:

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9
Q

Acetylcholine binds to nicotinic receptor is an example of which type of gated channel ?

A

Ligand gated

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10
Q

What are the two types of ligand channels ?

A

Sensors located extracellularly
Sensors located intracellularly

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11
Q

Pacinian corpuscle in skin is an example of which channel ?

A

Mechanical

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12
Q

T/F: A diffusion potential is the potential
difference generated across a membrane
when a charged ion diffuses against its
concentration gradient.

A

False down

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13
Q

Which of the following would INHIBIT diffusion potential from being generated ?
A)large conc. gradient
B) low conc. gradient
C)permeable membrane
D)impermeable membrane

A

D

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14
Q

The magnitude (amount) of a diffusion
potential is measured in

A

millivolts (mV)

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15
Q

The magnitude (amount) of a diffusion
potential depends on

A

size of concentration gradient

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16
Q

The sign of diffusion potential depends on

A

the charge of diffusing ion

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17
Q

when diffusion slows and then
stops; and there is no net movement of that ion; a stage called

A

Equilibrium
potential

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18
Q

is the Diffusion potential that exactly balances
or opposes the tendency for diffusion down the concentration difference.

A

Equilibrium potential

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19
Q

Current flow depends

A

Net force ( conc. and electrical)
Membrane permeability

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20
Q

What ion has opposing forces and what are its opposing forces ?

A

Potassium
Electrical gradient attracts it inside
Conc. gradient attracts it outside

21
Q

What is the equilibrium potential of potassium ?

A

-94 millivolts with negativity inside and positivity outside.

22
Q

What ion has 2 forces working together to move it ? What are they

A

Sodium
Electrical and conc. gradients both move sodium into the cell

23
Q

What is the equilibrium potential of sodium ?

A

Equilibrium potential for Na+ is +61 mv with
positivity inside and negativity outside

24
Q

Equilibrium potential for cl-

A

-65 (-63)

25
Q

to calculate the equilibrium potential for an ion at a given
concentration difference across a membrane, assuming that membrane is permeable to that ion.
The equilibrium potential is calculated for one ion at a time.

A

The Nernst equation

26
Q

————————the convert of concentration difference of an ion into a voltage at a given
temperature, gas and faraday constant

A

Nernst potential for that ion.

27
Q

Nernst potential magnitude depends on

A

Proportionally with the ratio of concentrations of that specific ion on two sides of
the membrane

28
Q

Formula of nernst

A

E (millivolts) = ± 61x log concentration inside/ concentration outside

29
Q

equation is used to determine the resting membrane potential
(RMP) in the cell with involvement of Na, K and Cl ions; the 3 most
important ions responsible for developing membrane potential

A

Goldman-Hodgkin-Katz equation

30
Q

When a membrane is permeable to several different ions, then resulting
diffusion potential depends on 3 factors:

A

1.Electrical charge of each ion
2. Permeability of membrane to that specific ion
3. Concentration of ions inside and outside the membrane

31
Q

resting membrane potential
(RMP) in the cell with involvement of Na, K and Cl ions equals to

A

-86 mV

32
Q

when membrane is not responding to any stimulus is called

A

resting membrane potential [RMP].

33
Q

What type of potential establishes RMP

A

Diffusion potential

34
Q

What is the RMP in a large nerve ?

A

-90mV

35
Q

The EP of highly permeable ions is closer to the value of the RMP due to their high permeability ?

A

Yes ie potassium

36
Q

What channels are important for resting membrane potential ?

A

K leaky channels and Na K pump

37
Q

T/F: Having a membrane potential does not make membrane excitable

A

True

38
Q

Excitability depends upon

A

the possibility of depolarization or reversal
of polarised potential

39
Q

——————- open in response to a stimulus and allow particular
ions to pass through and to change the polarized state to depolarized
state.
A) leaky channels
B)gated channels
C) EP
D) current flow

A

B

40
Q

GP channels :

A

ligand gated or mechanically gated
ion channel

41
Q

GP are produced at

A

dendrites and
soma of neuron

42
Q

Hyper polarisation signals cause what kind of graded potential?

A

IPSP

43
Q

Depolarisation graded potential causes what kind if signal

A

EPSP

44
Q

the part of neuron from
where axon arises

A

Axon hillock

45
Q

is the part of axon hillock
where action potential is produced.

A

Initial segment

46
Q

chemical and electrical forces acting on
that ion are equal and no further net diffusion of that ion occurs

A

electrochemical equilibrium,

47
Q

RMP in a large nerve with the na pump contribution =

A

-90

48
Q

Area in nerve rich in voltage gated Na+ channels

A

Trigger zone in initial segment

MSK Quiz 1 (9 decks)

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