tolerance

Question 1

what is central T-cell tolerance

Answer 1

eliminating self reactive T-cells in the thymus

Question 2

what is tolerance

Answer 2

the prevention of an immune response against a particular antigen

Question 3

what is an example of tolerance

Answer 3

the immune system is tolerant of self-antigens - so does not attack the body’s own cells

Question 4

what happens when tolerance in the body is lost

Answer 4

autoimmune disease
food allergy

Question 5

what are self reactive cells

Answer 5

cells that can produce antibodies that react against the body’s own substances
they are kept in the bone marrow/thymus + removed

Question 6

what happens if self reactive helper T-cells escape the thymus

Answer 6

they help B-cells make antibodies against host proteins

Question 7

thymus epithelial cells express which class of MHC

Answer 7

Class I MHC

Question 8

thymic dendritic cells express which type of MHC class

Answer 8

class II MHC

Question 9

how are immature T cells sorted into being cytotoxic to helper T-cells

Answer 9

(immature T-cells are double positive for CD4 and CD8)
MHC to peptide binding affinity is tested.