tolerance Flashcards

1
Q

what is central T-cell tolerance

A

eliminating self reactive T-cells in the thymus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

what is tolerance

A

the prevention of an immune response against a particular antigen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

what is an example of tolerance

A

the immune system is tolerant of self-antigens - so does not attack the body’s own cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

what happens when tolerance in the body is lost

A

autoimmune disease
food allergy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

what are self reactive cells

A

cells that can produce antibodies that react against the body’s own substances
they are kept in the bone marrow/thymus + removed

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

what happens if self reactive helper T-cells escape the thymus

A

they help B-cells make antibodies against host proteins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

thymus epithelial cells express which class of MHC

A

Class I MHC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

thymic dendritic cells express which type of MHC class

A

class II MHC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

how are immature T cells sorted into being cytotoxic to helper T-cells

A

(immature T-cells are double positive for CD4 and CD8)
MHC to peptide binding affinity is tested.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly