tolerance Flashcards
what is central T-cell tolerance
eliminating self reactive T-cells in the thymus
what is tolerance
the prevention of an immune response against a particular antigen
what is an example of tolerance
the immune system is tolerant of self-antigens - so does not attack the body’s own cells
what happens when tolerance in the body is lost
autoimmune disease
food allergy
what are self reactive cells
cells that can produce antibodies that react against the body’s own substances
they are kept in the bone marrow/thymus + removed
what happens if self reactive helper T-cells escape the thymus
they help B-cells make antibodies against host proteins
thymus epithelial cells express which class of MHC
Class I MHC
thymic dendritic cells express which type of MHC class
class II MHC
how are immature T cells sorted into being cytotoxic to helper T-cells
(immature T-cells are double positive for CD4 and CD8)
MHC to peptide binding affinity is tested.