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Immune > TMN1 and 2 > Flashcards

TMN1 and 2 Flashcards

1
Q

NK is part of ….immunity

A

INNATE

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2
Q

Digestive enzyme in mouth is ….. barrier

A

PHYSICAL BARRIER

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3
Q

Stomach acid is a …..

A

PHYSICAL BARRIER

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4
Q

MUCOUS and CHEMICAL secretions are …. barrier

A

PHYSICAL BARRIER

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5
Q

Defensin are….

A

antimicrobial peptides

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6
Q

Without …. infections would go unchecked and wounds would NOT heal

A

INFLAMMATION

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7
Q

Is this sequence correct: Edema, PMN, Monocyte/Macrophage, Tissue repair and regeneration (FROM INITIATION to RESOLUTION) steps of INFLAMMATION

A

Correct

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8
Q

For acute inflmmation, what happen prior to arrival of PMN

A

Edema

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9
Q

Monocyte/Macrophage arrive ….. PMN

A

AFTER

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10
Q

Parasite’s …. is recognized by immune system

A

GPI anchor

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11
Q

Innate is triggered by

A

PAMPs and DAMPs

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12
Q

peptidoglycan is a ….

A

PAMPs

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13
Q

CpG DNA is a…

A

PAMPs and DAMPs!

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14
Q

Flagellin is a….

A

PAMPs

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15
Q

Lipteichoic Acid is found in ….bacteria and is a ….

A

GRAM POSITIVE, PAMP

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16
Q

Viral sRNA is ….

A

PAMPs

17
Q

LPs is a….

A

PAMPs

18
Q

Viral dsDNA is a….

A

PAMPs

19
Q

TLRs are w/in …. and can also be …..

A

Vesicles or Membrane Bound

20
Q

…. are cytoplasmic Pattern Recognition Receptors

A

NOD like Receptor

21
Q

….use MyD88 or TRIF for signal transduction

A

Toll-like Receptor Family

22
Q

….discovered in drosphilia

A

TLR

23
Q

….located in endosome

A

TLR3, TLR7, TLR9, TLR8

24
Q

….use NF-kB

A

TLR

25
Q

….critical linke b/w innate and adaptive

A

TLR

26
Q

NLR’s names are based on….

A

their N-Terminal effector domains

27
Q

……common to all NLR

A

Nucleotide-binding domain (NOD)

28
Q

……c-terminal leucin Rich Repeat

A

NLR

29
Q

……variable N-terminal interaction Domain

A

NLR

30
Q

NOD1 and 2 act as ….sensors of ……

A

NOD1 and NOD2 act as INTRACELLULAR sensors of BACTERIAL INFECTION

recognize bact cell wall frag

proteoglycans

viral RNA

31
Q

…..involved in inflammasome formation and activated by PAMPs and DAMPs

A

NLRPs

32
Q

inflammasome activates…. which activates…. and …….

A

inflammasome of NLRPs activate CASPASE-1 which activates IL-1beta (from Pro-IL-1Beta) and IL-18 (from pro-IL-18)

33
Q

NFkB drives …… and ….. gene transcription

A

prol-IL-1beta and pro-IL-18 and infalmmasome component NLRP3 example gene transcription

Immune (6 decks)

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