tlr function innate immunity

Question 1

tlr

Answer 1

innate immunity
function is to recognise component of pathogen and activate immune response
bridge between innate and adaptive immunity
leucine rich region in external domain

Question 2

tlr 1 
 2
3
4
5
6
7
9

Answer 2

1- triaceylated liprotein 
2 diaceylated liprotein 
3 -  dsRNA  WITH TRIF adaptor not normal one
4 LPS
5 flagella 
9  cpG dna

Question 3

domain

Answer 3

myD88 adaptor
except for TLR3
involved in ifnalamtory response moedulation
tlr4 also has indepdent pathway of myd88 too
proline rich but if substituted for histadine there is no signalling

binds to TIR region of the TLR
acts as a bridge to IRAK 1-4 and TRAF6

Question 4

what happens with irak1,4 traf6

Answer 4

as disassociation occurs, activates protein kinases

NFKbeta - release of nfkbeta to activate assed genes
MAPK pathway -transcriptation factors release activate genes

Question 5

tlr3 blocked by

Answer 5

hcv

Question 6

function of mfkbeta

Answer 6

downreg inflammatory cytokines and chemokines