T cell receptor and MHC

Question 1

MHC stands for

and is also known as

Answer 1

major histocompatibility complex

HLA- human leucocyte antigen

Question 2

How was theory of MHC derived?

Answer 2

Noticed graft from A variant placed in A host-> accepted graft
if graft from b inserted into A, rejected
B to AB accepted
AB to B rejected
thus must be something determining ‘self’ and ‘non self’

Question 3

HLA positions

Answer 3

chromosome 6
Class 1 -957 ALLELES -> self antigen but can be modified by cancer and infection
CLASS 2- 630 ALLELES - non self antigen - from phagocytosed infected cells

class 1 - associated with ABC regions 
class 2- DR,DQ, DM and D something else 
 class 3

Question 4

t cells are restricted to what?

Answer 4

specific RESPONSE depending on specific ALLELE of MHC1 an MCH11 specific for an ANITGEN

Question 5

tested with type A mouse and virus X with HC

Answer 5

A mouse + X virus = response
A mouse+ no virus = no response
A mouse + Y virus = no response
b mouse and X virus- no response

Question 6

structure

Answer 6

MHC is specific for peptide

MHC[ peptide ] TCR

Question 7

MHC1 and MHC11

Answer 7

mhc1 - alpha 1,2,3, beta 2 microglobin
mhc11 beta 1 beta 2 alpha 1 alpha 2
on phospholipid membrane of surface of cell

Question 8

endogenos and exogenous action

Answer 8

endo mch1

exo mhc2

Question 9

MHC1 assn with….

Answer 9

interaction with cytotoxic CD8 cells with its TCR for cell death of a virally infected cell

Question 10

MHC 11 assn with…

Answer 10

interation with TCR of a CD 4 HELPER CELL stimulates th1 and th2 response

Question 11

gene arrangement

Answer 11

VDJC on B chains and similar on alpha chains
allows selection of t cells recognition of correct combination
those which are not selected do not proliferation

Question 12

two signals..

Answer 12

1. mhc peptide ith co receptor
   2 cd28 by BF-1 ligand or B7H2 ICOS for second signal
   some have inhibitory signals when bound to ligand which inhibit function such as CTLA4 and PD-1

Question 13

NKC

Answer 13

innate immune cepp
cyotoxic effect
express activating or inhibiting receptors
cytoxocity activite mediated by presence or absence of pos and neg signals depending on APC and receptor
Class 1 recognised and switched off to self antigen
switched on in cancer which expresss ligands, and proteins produced in cancer can overcome this inhibition
down regulation also on cancer preventing t cell recognition via no MHCHC missing self

Question 14

applications

Answer 14

blood group and donor matching rejection etc in transplants
acitivity of cancer why certain things occur and do not occur assn with cellkiling
activating of NKC and cancer which can also expres inhibitory cells