steatohepatitis

Question 1

steatohepatitis

Answer 1

presence of hepatocellular inflammation with steasosis in hepatocytes
can lead onto fibrosis cirrhosis and its commplications
disruption of liver architecture

Question 2

immune mediated mechanism

Answer 2

through inate inflammatory cells such as neutrophils ad mnocyte and asaptive immune cells with include t cells

Question 3

oxidative stress

Answer 3

inflammation cause ox stress and release of increase TNF alpha IL6 and IL1beta
stellate cell activatin 
ncrease in reative oxygen species
increase in NEFA oxidation 
ER stress

Question 4

histology

Answer 4

ballooning hepatocytes
steatosis
inflammation 
lobular inflammatory cell infilteration 
fibrosis

Question 5

two hit hypothesis

Answer 5

first hit : steatosis sensitisizes liver to inflammatory induction
insult promotes oxidative stress resulting steatohepatitis

Question 6

other things..

Answer 6

increase in adiopocytes in size, hypertrophy eventuallyresults in rupture and recruits inflammatory cells to site
this stimulations adiopcytokine production

Question 7

abberant immune response activtion

Answer 7

inflammation which impairs nsulin to inhibit free fatty acids causing accumulation in liver and results in liptoxicity

insulianceresistance and low grad inflam

Question 8

gut dysbiosis mech

Answer 8

dybosis in gut with liposacchride of acteria which causes nflammation nd macrophage polarisation
colonic inmmune fibrosis
cause by dysbiosis where tlr4 binds to LPS and inducts dimersation
and signalling cascade is activation
prdcution of inflammation cytokines tnfalpha resulting ijn fibrosis of liver

Question 9

how alcohol works

Answer 9

alcohol can increase gut permeability, increase LPS and bacterial transplocation into the blood, ncrease steatosis n liver
macrophages are marker of neutorpil of activation