hepatitis A

Question 1

hep A which virus
prevalence 
transmission
countries
symptoms 
features of virus

Answer 1

pircornivirus
20million
FO
Africa south America asia
jaundice, fatigue, weight loss, loss of apetitie, abdo pain
highly reisstance to acid, temperature stable at low ph allowing for longevity

Question 2

onset

Answer 2

5-12 weeks

ACUTE

Question 3

igM and IgG

alt

Answer 3

elevated ALT

then increase in igM and igG providinglong term immunity

Question 4

genome

Answer 4

VP 1-3 proteins required for capsid
v2p2 has vp4
single ORF and single stranded

nnon structural proteins include helicase and protease for HOST DEFENSE MECHANISMS
5 end vpg site acting as prmer for polymerase to bin and
possess internal ribosomal entry site for loading of this protein

Question 5

replication

Answer 5

igA HAV binding onto tim receptor of hepatocyte
receptor mediated endocytosed ninto clel
cap independent translation and proteolytic activity post translation occur
negative strand synthesis
psotive strand synthesis
increase in this synthesis
packed into viral particles
leaves hepatocyte through membrane fusion

Question 6

cloaking

Answer 6

the HAV leave hepatocyte viaapical membrane to enter bile canniculi to SI to faeces
OR
cloaked mechanism via basolateral membrane through a hijacking mechanism which provides virus eith evelope to form eHAV to reinfect neighbouring cells
HAV interferes with RIG1 ad TCR3 inhibiting ifn production where ehav interacts with PDC cells to increase iFN production
immunopathic injury induces CD8 for IFN and inflame cell recruitment