Tissue repair Flashcards
Parenchymal
Tissues that contain the functioning cells of an organ or body part
Stromal tissues
Consist of supporting connective tissues, blood vessels, extracellular matrix, and nerve fibers
Labile cells
continue to divide and replicate throughout life, replacing cells that are continually being destroyed
Stable cells
Normally stop dividing when growth ceases
Permanent Cells
Cannot undergo mitotic division
Primary healing
small clean wound
Secondary healing
great loss of tissue with contamination
Extracellular Matrix (ECM)
-Fibrous structural proteins (Collagen and elastin fibers
-Water-hydrated gels that permit resilience and lubrication (Proteoglycans and hyaluronic acid)
-Adhesive glycoproteins that connect the matrix elements to each other and to cells (fibronectin and laminin)
Basement membrane
surrounds epithelial, endothelial, and smooth muscle cells
Interstitial matrix
Present in spaces between cells the connective tissue and between the epithelium and supporting cells of blood vessels
Stages of wound healing
Inflammatory
Proliferative
Maturational/remodeling
Two phases of scar formation
emigration and proliferation of fibroblasts into the site of injury
Deposition of the ECM by these cells
Immediate transient response
occurs with minor injury
Immediate sustained response
occurs with more serious injury and continues for several days and damages the vessels in the area
Delayed hemodynamic response
involves an increase in capillary permeability that occurs 4 to 24 hours after injury
