Tissue Architecture

Question 1

Which of the cytoskeletal elements does not participate in motility?

Answer 1

intermediate filaments

Question 2

Taxol, colchicine and vinblastine target which cytoskeletal element?

Answer 2

microtubules

Question 3

Cytoskeletal elements form smallest to largest?

Answer 3

microfilaments, intermediate filaments, microtubules

Question 4

Which cytoskeletal element makes up the mitotic spindle?

Answer 4

microtubules

Question 5

Which cytoskeletal element participates in cell division?

Answer 5

microfilaments

Question 6

Which cytoskeletal element participates in chromosomal stability and structural support of plasma membrane?

Answer 6

intermediate filaments

Question 7

Which cytoskeletal element is found in pseudostratified ciliated cell?

Answer 7

microtubules

Question 8

Phalloidin, cytochalasin and latrunculin prevent polymerization of what element?

Answer 8

microfilaments

Question 9

Where does hydroxylation/glycosylation of collagen take place?

Answer 9

lumen of ER

Question 10

Where is pre-collagen translated?

Answer 10

RER

Question 11

What are the 3 components of ECM? Which one is the main one?

Answer 11

1. proteoglycans,
2. COLLAGEN
3. matrix proteins (3: laminin, fibronectin and entactin)

Question 12

What assists the self assembly of tropcollagen?

Answer 12

disulfide bonds

Question 13

Self assembly of collagen into fibers occurs where?

Answer 13

extracellular space

Question 14

Which type of junctions that we learned has both cell to cell and cell to ECM adhesions?

Answer 14

Anchoring junctions (ex. desmosomes, hemidesmosomes)

Question 15

Which of the adhesion molecules families is Ca2+ INDEPENDENT? Give examples

Answer 15

Ig CAMS ( VCAM, ICAM … MAdCAM)

Question 16

____ levels of E cadherin and ____ levels of N- cadherin indicate?

Answer 16

LOW , HIGH

indicate: high metastatic potential and ^^^ invasiveness

Question 17

What is a unique property of collagen?

Answer 17

it is TRIMERIC

Question 18

Which of the 4 families binds to carbohydrates

?

Answer 18

selectins

Question 19

Which of the 4 families exhibits both homophilic and heterophilic binding?

Answer 19

Ig CAMS

Question 20

Which of the adhesion molecules interacts with cytoskeleton (actin)?

Answer 20

Cadherins

Question 21

Which adhesion molecules activate signaling pathways via RTKs?

Answer 21

Integrins

Question 22

What affinity do selectins have and why ?

Answer 22

LOW: to allow leukocyte rolling