Tissue Architecture Flashcards
Which of the cytoskeletal elements does not participate in motility?
intermediate filaments
Taxol, colchicine and vinblastine target which cytoskeletal element?
microtubules
Cytoskeletal elements form smallest to largest?
microfilaments, intermediate filaments, microtubules
Which cytoskeletal element makes up the mitotic spindle?
microtubules
Which cytoskeletal element participates in cell division?
microfilaments
Which cytoskeletal element participates in chromosomal stability and structural support of plasma membrane?
intermediate filaments
Which cytoskeletal element is found in pseudostratified ciliated cell?
microtubules
Phalloidin, cytochalasin and latrunculin prevent polymerization of what element?
microfilaments
Where does hydroxylation/glycosylation of collagen take place?
lumen of ER
Where is pre-collagen translated?
RER
What are the 3 components of ECM? Which one is the main one?
- proteoglycans,
- COLLAGEN
- matrix proteins (3: laminin, fibronectin and entactin)
What assists the self assembly of tropcollagen?
disulfide bonds
Self assembly of collagen into fibers occurs where?
extracellular space
Which type of junctions that we learned has both cell to cell and cell to ECM adhesions?
Anchoring junctions (ex. desmosomes, hemidesmosomes)
Which of the adhesion molecules families is Ca2+ INDEPENDENT? Give examples
Ig CAMS ( VCAM, ICAM … MAdCAM)
____ levels of E cadherin and ____ levels of N- cadherin indicate?
LOW , HIGH
indicate: high metastatic potential and ^^^ invasiveness
What is a unique property of collagen?
it is TRIMERIC
Which of the 4 families binds to carbohydrates
?
selectins
Which of the 4 families exhibits both homophilic and heterophilic binding?
Ig CAMS
Which of the adhesion molecules interacts with cytoskeleton (actin)?
Cadherins
Which adhesion molecules activate signaling pathways via RTKs?
Integrins
What affinity do selectins have and why ?
LOW: to allow leukocyte rolling
