Tirofiban

Question 1

Brand name of Tirofiban

Answer 1

Aggrastate

Question 2

Drug class of Tirofiban

Answer 2

Glycoprotein IIb/IIIa inhibitor, platelet aggregation inhibitor

Question 3

Mechanism of action for Tirofiban

Answer 3

Inhibits aggregation of platelets by reversibly antagonizing fibrinogen binding to the Glycoprotein IIb/IIIa receptor site

Question 4

Indications for Tirofiban

Answer 4

Used with heparin to provide anticoagulant in hospital as patient’s undergo angioplasty or PCI

Question 5

Contraindications for Tirofiban

Answer 5

Trauma, surgery within 30 days, hemorrhagic stroke, intracranial neoplasm, AV malformation Aneurism, Aortic dissection, systolic BP of >180 diastolic BP of >110

Question 6

Adverse affects of Tirofiban

Answer 6

dizziness, pain, diaphoresis, bleeding, CVA, bradycardia, coronary artery dissection, N/V, fever, and headache

Question 7

Precautions for Tirofiban

Answer 7

Do not use with other Glycoprotein IIb/IIIa inhibiors, caution with patients with platelet count of < 150,000

Question 8

Dose for Tirofiban

Answer 8

0.4 mcg/kg/min for 30 mins (loading dose), 0.1 mcg/kg/min for 10 to 24 hrs (maintenance dose)