Thyroid Risk Factors And Complications Flashcards
Why is hypothyroidism a risk factor for hypercholersterolaemia?
The liver requires thyroxine in order to stimulate cholesterol uptake from serum.
When someone is hypothyroid, their liver doesn’t uptake as many LDLs, and so we have cholesterol building up in serum, and the risk factor for ACS, CAD, stroke, TIA etc
What are the risk factors for postpartum thyroiditis?
Recent birth.
History of type 1 diabetes mellitus.
What are the risk factors for hypothyroidism?
Female gender (10 times more likely to have Hashimoto’s than men)
Age 40+
Family history of thyroid disease
Family history of autoimmune disorders
Autoimmune disorders: T1DM, Addison’s disease, pernicious anemia
Turner and Down’s syndrome
Head and neck radiotherapy
Radioiodine treatment
Iodine deficiency
Amiodarone, interferon, rifampicin or lithium use
Past history of brain cancer or metastatic cancer
What are the risk factors for hyperthyroidism?
Family history of Graves’ disease
Family history or personal history of autoimmune disease (T1DM)
Female
Tobacco use
Low iodine intake
Interferon
Amiodarone
Rifampicin
Lithium
What are the complications of hyperthyroidism?
AF
Angina
Neonatal hyperthyroidism (A pregnancy complication: antibodies crossing the placenta)
Osteoporosis
Liver derangement (due to thyroxine affecting it too much: LDL uptake)
Which type of thyroid cancer is associated with phaeochromocytoma (adrenal tumour)?
Medullary cell carcinoma
The second most common thyroid cancer.
Which is at risk of osteoporosis: hypothyroidism or hyperthyroidism?
Hypothyroidism: they have no thyroxine suppression of osteoclast activity.
