Thyroid physiology Flashcards
1
Q
What do parafollicular C cells secrete?
A
Calcitonin
2
Q
How are T3 & T4 made?
A
Iodine + Tyrosine = MIT + DIT
(MIT + DIT = T3)
(DIT + DIT = T4)
3
Q
Which plasma proteins are used to transport T3 & T4 in the blood?
A
TBG
TBPA
Albumin
4
Q
Where is T4 converted to T3?
A
Liver & Kidneys
5
Q
Which conditions can cause an increase in TBG?
A
Pregnancy OCP Tamoxifen Hep A Billiary cirrhosis Acute intermittent porphyria Clofibrate Heroin
6
Q
What conditions cause a decrease in TBG?
A
Cushings Androgens Acromegaly Severe systemic illness Nephrotic syndome Phenytoin Carbamzepine
7
Q
What stimulates TSH release form the pituitary?
A
TRH from hypothalamus
8
Q
Cardiovascular effects of T3/4
A
Increase CO
Increase HR
Increase Respiration
9
Q
Metabolic effects of T3/T4
A
Increase O2 consumption Increase glucose absoprtion Increase gluconeogenesis Increase glycogenolysis Increase lypolysis Increase protein synthesis Increase BMR
