Thyroid Pharm Flashcards
Synthroid
Levothyroxine
Levothroid
Levothyroxine
Levothyroxine
First line for hypothyroid
synthetic T4
Once Daily
Levothyroxine SE
Should be taken on empty stomach
Caution in cardiac. Interact w/adrenergic effects or decongestants
Liothyronine
Synthetic T3
Short half life = not for routine use hypothyroidism
Avoid in cardiac disease
Liotrix
4:1 T4/T3
$$$
Rarely recommended
For hypothyroidism but may cause low TSH
Thyroid USP or Strong
Porcine thyroid extract
Protein antigenicity
Not recommended
Methimazole
Thionamide
Preferred
Propylthiouracil
Thionamide
Safer in pregnancy
But more hepatotoxicity
Thionamide
Block iodine organification
Caution in in pregnancy
Best for mild hyperthyroidism or younger patients
Thionamide SE
pruritic rash, gastric intolerance, arthralgias,
Agranulocytosis
SSKI
Iodides
Lugol’s solution
Iodides
Iodides
High doses inhibit TH synth
Rarely used alone for hyperthyroid
Initiate after thionamide therapy
Radioactive Iodine
Slowly destroys gland for hyperthyroidism
Patients > 21
Contraindicated in pregnancy
80% get hypothyroidism instead