Ca Drugs

Question 1

Ca Carbonate

Answer 1

Chronic hypoCa
Adolescents: 1300 mg
Old: 1200 mg
Most others: 1000 mg
Greatest % Ca
Take with food

Question 2

Ca Citrate

Answer 2

Chronic hypoCa
Adolescents: 1300 mg
Old: 1200 mg
Most others: 1000 mg
B/w meals

Question 3

Ca Gluconate

Answer 3

IV 
Severe acute hypoCa
Adolescents: 1300 mg
Old: 1200 mg
Most others: 1000 mg

Question 4

Furosemide

Answer 4

Loop diuretic
Up Ca excretion
Use for hypercalcemia

Question 5

Cholecalciferol

Answer 5

D3
preferred agent because of modest cost and efficacy
70 yrs: 800 IU

Question 6

Ergocalciferol

Answer 6

D2

Less efficient than D3

Question 7

Calcifediol-25(OH)D3

Answer 7

Doesn’t require liver hydroxylation, so useful in liver disease

Question 8

Calcifediol-25(OH)2 D3

Answer 8

best for patients with decreased synthesis of calcitriol (i.e. Vit D Dependent Ricket’s Type 1, chronic renal failure)

Question 9

Alendronate

Answer 9

Bisphosphonates

1x/wk

Question 10

Risedronate

Answer 10

Bisphosphonates

1x/wk

Question 11

Zoledronate

Answer 11

Bisphosphonates

1x/yr

Question 12

Bisphosphonates

Answer 12

Pyrophosphate analogs incorp in bone
Promote osteoclast apoptosis and inhibit fxn
First line in osteoporosis & hyperCa of malignancy

Question 13

Bisphosphonates SE

Answer 13

GI, esophagitis, osteonecrosis of jaw

Question 14

Raloxifine

Answer 14

SERM

Question 15

SERMs

Answer 15

Selective Estrogen Receptor Modulators
Decreases osteoclast activity (induce OC apoptosis) & up OPG
2nd line osteoporosis. If can’t take bisphosphonates or invasive breast cancer.

Question 16

SERM SE

Answer 16

hot flashes, leg cramps, risk of thromboembolic disorders

Question 17

Teriparatide

Answer 17

PTH Analog - up osteoblastic act
$$$
SE: nausea, HA, dizziness, muscle pain

Question 18

Miacalcin

Answer 18

Nasal calcitonin
Inhibit osteoclast bone resorption
Tx for osteoporosis
SE: Rhinitis and epistaxis

Question 19

Denosumab

Answer 19

RANK-L Ab - prevent from activating OC
Pts at high risk for fractures or 
unresponsive to bisphosphonates

Question 20

Hydrochlorothiazide

Answer 20

Thiazide - decrease Ca excretion

For hypercalciuria

Question 21

GC for Ca

Answer 21

Decrease Ca absorb, up Ca excretion.

For Chronic hypercalcemia