Adrenal Pharm Flashcards
Hydrocortisone
Equal GC & MC activity
Oral & parenteral
Prednisone
Glucocorticoid mainly
Activated in liver = no topical effect
Dexamethasone
Glucocorticoid, minimal MC
Most potent anti-inflammatory
Greatest ACTH supression
Also for cerbral edema, & chemo vomiting
Fludrocortisone
Mineralocorticoid
Glucocorticoid Enzymes
11-beta-HSD1 in liver activating
11beta-HSD2 in kidneys inactivating
Antiinflam GC Effects
Inhibit Phospholipase A2 & COX2
Want GC only
Immunosuppressive GC
supress T cell activation, cytokine production, mast cell & eosinophils from releasing
GC only
AI drugs
Cortisol & fludorcortisone (GC & MC)
Cushing’s Drugs
Ketoconazole - synth inhibitor
Mifepristone - GC antag
Pheochromocytoma Drugs
First: Alpha block (Phenoxybenzamine, Prazosin,
Terazosin, Doxazosin), then Beta block (metoprolol)
Or Ca block alone (nifedipine)
GC SE
Up glucose, muscle wasting & connective tissue degen
Centripetal fat deposition
MC SE
Incease Na = Up BP
Increase water = edema
Increase K & H secretion = hypoK and Metabolic alkalosis
Triamcinolone
Topical
No MC