Adrenal Pharm Flashcards

1
Q

Hydrocortisone

A

Equal GC & MC activity

Oral & parenteral

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2
Q

Prednisone

A

Glucocorticoid mainly

Activated in liver = no topical effect

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3
Q

Dexamethasone

A

Glucocorticoid, minimal MC
Most potent anti-inflammatory
Greatest ACTH supression
Also for cerbral edema, & chemo vomiting

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4
Q

Fludrocortisone

A

Mineralocorticoid

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5
Q

Glucocorticoid Enzymes

A

11-beta-HSD1 in liver activating

11beta-HSD2 in kidneys inactivating

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6
Q

Antiinflam GC Effects

A

Inhibit Phospholipase A2 & COX2

Want GC only

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7
Q

Immunosuppressive GC

A

supress T cell activation, cytokine production, mast cell & eosinophils from releasing
GC only

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8
Q

AI drugs

A

Cortisol & fludorcortisone (GC & MC)

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9
Q

Cushing’s Drugs

A

Ketoconazole - synth inhibitor

Mifepristone - GC antag

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10
Q

Pheochromocytoma Drugs

A

First: Alpha block (Phenoxybenzamine, Prazosin, 
Terazosin, Doxazosin), then Beta block (metoprolol)
Or Ca block alone (nifedipine)

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11
Q

GC SE

A

Up glucose, muscle wasting & connective tissue degen

Centripetal fat deposition

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12
Q

MC SE

A

Incease Na = Up BP
Increase water = edema
Increase K & H secretion = hypoK and Metabolic alkalosis

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13
Q

Triamcinolone

A

Topical

No MC

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