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Pharm II > Thyroid & Osteoporosis > Flashcards

Thyroid & Osteoporosis Flashcards

0
Q

calcitonin adverse effects (3)

A

allergic rxn (fish sensitivity)
nasal rhinitis/sinusitis (nasal spray)
N/V (injection)

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1
Q

calcitonin (miacalcin) effects (4)

A

decrease bone resorption of Ca
antagonizes PTH
decrease bone pain & loss
increase bone density

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2
Q

teriparatide (forteo) MOA & effects (3)

A

recombinant PTH

stimulates remodeling
causes bone resorption
new bone growth formation

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3
Q

teriparatide contraindication

A

osteosarcoma or risk for osteosarcoma

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4
Q

denosumab MOA

A

antibody to RANKL, the factor made by osteoblasts that is necessary for the formation of mature osteoclasts

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5
Q

denosumab effect

A

inhibits bone resorption

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6
Q

denosumab indications/effects (2)

A

osteoporosis in men and post-menopausal women at high fracture risk
increase bone mass & strength in both cortical and trabecular bone

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7
Q

denosumab adverse effects (2)

A

hypocalcemia

osteonecrosis of the jaw

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8
Q

denosumab absolute contraindications (2)

A

hypocalcemia (fix it first)

pregnancy

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9
Q

IV bisphosphonates (4)

A

Ibandronate (Boniva)
Zoledronic acid (Zometa)
Etidronate (Didronel)
Pramidronate (Aredia)

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10
Q

oral bisphosphonates (4)

A

Alendronate (Fosamax)
Risedronate (Actonel)
Ibandronate (Boniva)
Etidronate (Didronel)

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11
Q

oral bisphosphonates adverse effects

A

GI irritation

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12
Q

IV bisphosphonates adverse effects

A

renal toxicity if given too quickly

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13
Q

bisphosphonates use (2)

A

DOC for post-menopausal women and men with osteoporosis

Paget’s disease

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14
Q

bisphosphonate MOA (4)

A

substitutes for PO4 in Ca binding
incorporates into bone
inhibits osteoclast activity
inhibits bone resorption

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15
Q

all bisphosphonates adverse effects (4)

A

N/V
mild hypocalcemia
AFib
necrosis of the jaw after dental work

16
Q

thyroid hormone replacement (3)

A

Levethyroxine sodium
Liothyronine sodium
Liotric (Euthroid)

17
Q

inhibitors of thyroid hormone synthesis (4)

A

propylthiouracil
methimazole
iodides
radioactive iodine

18
Q

osteoporosis risk factors (5)

A 
post-menopausal
long term glucocorticoid use
thyrotoxicosis
alcoholism
malabsorption syndrome

Pharm II (14 decks)

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