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Pharm II > Anti-arrhythmics > Flashcards

Anti-arrhythmics Flashcards

0
Q

Class 1a MOA

A

preferentially block open or activated Na channels & K channels

slow rise of AP, prolong AP duration, prolong ERP

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1
Q

Class IA drugs (2)

A

Quinidine

Procainamide

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2
Q

Quinidine & Procainamide use

A

atrial & ventricular arrhythmias

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3
Q

quinidine adverse effects (4)

A

reflex tachycardia
paradoxical tachycardia
Torsades des Pointes
EKG changes

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4
Q

procainamide rare adverse effect

A

SLE in slow acetylators

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5
Q

Class 1B drug

A

Lidocaine

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6
Q

lidocaine MOA

A

block inactivated Na channels, shorten the duration of the AP

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7
Q

lidocaine use

A

DOC for acute ventricular arrhythmias

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8
Q

lidocaine side effects (4)

A

least toxic
least negative ionotropic
bradycardia
paresthesias

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9
Q

class 1C

A

flecainide

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10
Q

flecainide MOA

A

bind to all sodium channels

no effect on AP

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11
Q

flecainamide uses (3)

A

supraventricular arrhythmias
life threatening ventricular arrythmias
last ditch effort

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12
Q

flecainamide adverse effect

A

strong pro-arrhythmic effect

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13
Q

class 2 (3 drugs)

A

Propranolol
Acebutolol
Esmolol

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14
Q

class 3 (2)

A

Amiodarone

Sotalol

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15
Q

Amiodarone MOA (5)

A 
K+ channel inhibitor
Blocks Na+ channels
B-blocker
Some CCBs
alpha block
16
Q

Amiodarone uses

A

both atrial & ventricular arrhythmias

17
Q

Amiodarone adverse effects (4)

A 
Prolonged QT
Bradycardia
Pulm fibrosis
Deposited in tissues
Thyroid dysfunction
18
Q

Sotalol MOA (2)

A

K+ blocker

Non-selective B-blocker

19
Q

Sotalol uses

A

ventricular & supraventricular arrhythmias

20
Q

Sotalol adverse effects (2)

A

B-receptor blockade

Torsade de Pointes

21
Q

Class IV (2)

A

verapamil

diltiazem

22
Q

CCB uses (4)

A

Re-entrant supraventricular tachycardia
PSVT
A Fib
effects on the SA and AV nodes

23
Q

CCB side effects (3)

A

negative ionotropic action
constipation
AV block if used w/ B-blockers

24
Q

Adenosine MOA

A

enhances K+ conductance
inhibits cAMP-induced Ca influx
—> hyperpolarizes everything, restarts the heart

25
Q

Adenosine uses (3)

A

acute PVST
WPW syndrome
Effective only in re-entry arrhythmias

26
Q

Magnesium uses (4)

A

tx digitalis induced arrhythmias
DOC Torsades de Pointes
management of seizures, HTN w/ eclampsia

27
Q

Potassium uses (4)

A

decrease AP duration
decrease conduction
decrease pacemaker rate
decrease pacemaker arrhythmogenesis

28
Q

acute PVST treatment order (3)

A

Adenosine
Esmolol
CCB (IV)

29
Q

Chronic PSVT tx order (2)

A

B-blocker

CCB

Pharm II (14 decks)

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