Thyroid Eye Disase Flashcards

1
Q

If patient presents with bilateral proptotic eyes, what type of scan should we get?

A

CT scan

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2
Q

If a patient presents with a unilateral proptotic eye, what type of scan should we get?

A

MRI

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3
Q

In TED, whereever the eye cannot go, the ______ muscle is enlarged.

A

opposite

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4
Q

Absence o exophthalmos may mean what?

A

posterior decompression of ON

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5
Q

What’s the most reliable sign of TED?

A

Upper lid retraction

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6
Q

A patient that complains of their jelly roll edema in TED will say its worse when?

A

Worse when waking up and if they sleep on their back

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7
Q

When performing the curtain test, the left eye looks ptotic. You pin it up, what happens to the right eye if OS is truly ptotic?

A

OD will droop

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8
Q

What are the 3 muscles affected in TED consecutively?

A
  1. IR
  2. MR
  3. SR
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9
Q

If IR is affected, which way will the patient have problems looking?

A
  • issues looking up

- always opposite of swollen muscle

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10
Q

What will be the first ocular symptom of TED?

A

Dry eye

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11
Q

If patient has a hard time looking out, if you take IOP what will happen?

A

IOP will increase

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12
Q

What are the labs that should be ordered for a possible TED patient that has never been dx?

A
  1. Serum TSH
  2. T3 + T4
  3. Anti-thyroid antibodies
  4. Thyroid Stimulating Immunoglobulin (TSI)
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13
Q

Which lab workup is important to determine if TED is present

A
  • Anti-thyroglobulin Ab

- Thyroperosidase Ab

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14
Q

What can the patient to do decrease the symptoms of TED and have a better prognosis?

A

stop smoking!

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15
Q

What is the tx if there’s significant EOM enlargement?

A
  1. Oral steroids for acute tx

2. Orbital decompression if compressive optic neuropathy is present

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16
Q

When is the only time EOM muscle is allowed?

A

TED must be stable and not worsening (usually ~ 2 years)

17
Q

What % of MG patients will present with a thymoma?

18
Q

Does MG affect the pupils?

19
Q

If the patient has purely ocular MG, what will be the symptoms?

A

diplopia and ptosis

20
Q

If the patient has genralized MG, what will be their symptoms?

A

Ocular symptoms and upper/lower limb weakness

21
Q

MG is characterized by a decrease in the number of ____ receptors?

A

ACH receptors due to antibodies binding to them

22
Q

MG is found in what type of ppl?

A
  1. Young women = 15-20

2. Old men = 50-60

23
Q

60% of MG patients will have an initial presenting ocular sign. Why?

A

the low diplopic threshold

- a small misalignment of the eyes can cause DV

24
Q

When a MG patient looks down and then straight ahead, the upper lid overshoots and then comes back down. What’s this called?

A

Cogan’s lid twitch

25
MG patients have issues with what type of muscles?
Flexor muscles
26
What are the 3 ACH receptor antibodies found in a MG pt?
1. Binding 2. Blocking 3. Modulating
27
What is the best antibody lab workup to get if patient cannot afford to get all 3?
Binding !
28
If antibody testing came back negative but you still think the patient has MG, what's the next step?
1. Electomyography (EMG) | - in purely ocular MG, antibodies are only present 50% of time
29
An EMG tests for fatigability by repeatedly stimulating muscle nerve fibers from what 2 muscles?
1. Frontalis | 2. Orbicularis Oculi
30
A myasthenic ptosis worsens when?
In bright sunlight
31
When performing the ice pack test on a possible MG patient, how will the ptosis change?
Improves with cold | - cold blocks reuptake of Ach
32
Single fiber EMG is what % sensitive for MG? how long does it take?
95% sensitivity | takes 2 hours
33
What % of purely ocular MG convert to generalized MG? Most convert in what timeframe?
40-85% convert by 36 months
34
What is the most common tx for MG?
Mestinon - inhibits breakdown of ACh by ACHase
35
If your MG patient has kidney disease, how would you change the dosage of Mestinon?
- decrase the dosage | - Mestinon is excreted by the kidney
36
MG gets worse during what time of the day?
Toward the end of the day | - gets better with sleep