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Endo Week 2 > Thyroid Bump Pathology > Flashcards

Thyroid Bump Pathology Flashcards

1
Q

what are the three main changes seen in histo of multinodular goiter?

A

hyperplasia
colloid accumulation
nodule formation

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2
Q

what does colloid accumulation look like in multinodular goiter?

A

lots of colloid within one follicle

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3
Q

what does hyperplasia look like in multinodular goiter?

A

hypercellular area

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4
Q

how do follicular adenomas appear grossly?

A

they are well circumscribed and clearly a nodule

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5
Q

what are the histo findings of a follicular adenoma?

A

encapsulated area of hypercellularity, with normal thyroid outside of capsule

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6
Q

how do you differentiate between a follicular thyroid carcinoma and follicular adenoma?

A

follicular thyroid carcinoma will have either blood vessel or capsular invasion

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7
Q

what is the classic cell seen in follicular carcinoma?

A

hurthle cells..very light pink

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8
Q

what is main histo change to note in papillary thyroid carcinoma?

A

CYTOLOGiC appearance changes

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9
Q

what are the cytologic nuclear changes seen in papillary thyoid carcinoma?

A

crowded cells with nuclei dispersed and irregular nuclear contour

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10
Q

what is irregular about nuclear contour in papillary thyroid carcinoma?

A

nuclear grooves and intranuclear pseudoinclusions

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11
Q

what thyroid cancer has psammoma bodies?

A

papillary thyroid carcinoma

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12
Q

what can papillary thyroid carcinoma sometimes lead to in thyroid?

A

cystic space

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13
Q

how does medullary thyroid cancer appear on histo?

A

lots of packets of uniform oval blue cells and spindle shaped cells…all in C cell area

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14
Q

what three thyroid neoplasms are easily picked out on FNA?

A

papillary thyroid carcinoma
medullary thyroid carcinoma
anaplastic thyroid carcinoma

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15
Q

what two thyroid neoplasms are hard to decipher on FNA?

A

follicular adenoma and carcinoma

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16
Q

what will the ratio of colloid to cells be in a benign FNA of thyroid tissue?

A

more colloid than cells

17
Q

how does FNA appear in benign process?

A

pink colloid background with low cellularity

18
Q

what will the ratio of colloid to cells be in a malignant FNA of thyroid tissue?

A

low colloid and high cellularity

19
Q

what is appearance of hashimotos on FNA?

A

high cellularity due to inflammation, lots of lymphocytes

20
Q

how does a papillary thyroid carcinoma appear on FNA?

A

lots of papillary clusters with reduced colloid background, will also see classic nuclear signs

Endo Week 2 (8 decks)

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