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UNMC PA Pharmacology > Thyroid > Flashcards

Thyroid Flashcards

1
Q

Thyroid hormones are made in the ____ cells of the thyroid

A

Follicular

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2
Q

T_ is more potent than T_

A

T3 is more potent than T4

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3
Q

T4 is converted to __

A

T3

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4
Q

What hormone from the hypothalamus stimulates the anterior pituitary to release TSH?

A

TRH

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5
Q

Causes of hypothyroidism

A

Autoimmune/Hashimotos
Iodine deficiency
Pituitary dysfunction

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6
Q

Causes of hyperthyroidism

A

Autoimmune/Graves
TSH secreting qdenomq

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7
Q

Drug version of T4

A

Levothyroxine

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8
Q

Levothyroxine is ____ protein bound

A

Highly

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9
Q

Levothyroxine is ___ potent than liothyronine

A

Less potent

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10
Q

Levothyroxine can be given IV to treat what?

A

Myxedema coma

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11
Q

Uses of Levothyroxine

A

Hypothyroidism
Myxedema coma
Thyroid cancer (suppress TSH)
Post thyroid removal

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12
Q

Drug version of T3

A

Liothyronine

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13
Q

Liothyronine has ___ onset and ____ duration of action

A

Rapid onset
Short duration of action

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14
Q

Liothyronine is ___ protein-bound than Levothyroxine

A

Less (higher potentcy and rapid degeneration)

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15
Q

Clinical uses of liothyronine

A

Not used for chronic therapy
Short term for radioiodine treatment
Surgery for thyroid cancer to suppress TSH (only until T4 takes effect)

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16
Q

Side effect of thyroid replacement hormones

A

Hyperthyroid symptoms if overdosed

17
Q

Levothyroxine interacts with which drugs

A

Vitamin K-dependent clotting factors (warfarin)
Cqtecholamines

18
Q

Thioamide drugs

A

Methimazole
Propylthiouracil

19
Q

Thioamide MOA

A

Inhibit peroxidase enzyme
Does NOT inhibit release of preformed TH

20
Q

Clinical uses of thioamides

A

First line therapy for hyperthyroidism

21
Q

Side effects of thioamides

A

Agranulocytosis (life threatening)
Hypothyroidism

22
Q

Thioamide drug with higher potency and longer duration of action

A

Methimazole

23
Q

What is different about the MOA of propylthiouracil than methimazole?

A

Also converts T4 to T3 in addition to inhibiting peroxidase

24
Q

Hyperthyroidism treatment in pregnancy

A

Propylthiouracil in 1st trimester then switch to Methimazole

25
Q

Clinical uses of potassium iodide

A

Protection against thyroid damage from release of radioactive iodine from nuclear accidents
Thyroid storm
Prior to thyroidectomy to shrink gland

26
Q

Potassium iodide MOA

A

Acute inhibition of synthesis and release of THs
Decreases size and vascularity of thyroid gland

27
Q

Clinical uses of radioactive iodine

A

Small doses for iodine uptake tracer studies (hyperthyroidism diagnosis, locate cancer)
Large doses for destruction of thyroid

UNMC PA Pharmacology (23 decks)

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