Cholinergics Flashcards
Prototype muscarinic agonist
Acetylcholine
Acetylcholine is __ charged, so it can/can’t cross the BBB
Positively; can’t
Acetylcholine must be administered _____
Intravenously
Vascular effects of acetylcholine
Vasodilation due to stimulation of M3 receptors on vascular endothelium, causing release of nitric oxide
Decreased heart rate and contractility (M2 receptors)
Ophthalmic acetylcholine use
Complete miosis (pupil constriction/ciliary muscle contraction)
Prototype choline ester
Bethanechol
Bethanechol uses
Urinary retention
Synthetic choline ester function
More M-selective with prolonged action
Prototype alkaloid
Pilocarpine
Pilocarpine MOA
Agonist of all muscarinic receptors
Pilocarpine uses
Xerostomia/sjogrens
Glaucoma
Cevimeline MOA
Selective M1/M3 agonist alkaloid in lacrimal and salivary glands
Cevimeline uses
Sjogrens/xerostomia
Side effects of muscarinic agonists
Sweating, hypotension, cramping, diarrhea
Muscarinic agonist contraindications
Hyperthyroidism
Asthma
Peptic ulcer