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UNMC PA Pharmacology > Hematopoietics > Flashcards

Hematopoietics Flashcards

1
Q

Oral treatment for iron deficiency anemia

A

Ferrous sulfate

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2
Q

How long is anemia treatment with ferrous sulfate?

A

1-2 months

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3
Q

Prophylactic ferrous sulfate is given to ____ and ____

A

Pregnant people
People with menorrhagia

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4
Q

Main side effect of ferrous sulfate

A

GI upset

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5
Q

Treatment for iron toxicity

A

Deferoxamine (DFO)

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6
Q

Ferrous sulfate drug interactions

A

Antacids reduce absorption
Reduces tetracycline absorption

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7
Q

IM/IV treatment for iron deficiency anemia

A

Iron dextran

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8
Q

When is iron dextran given for iron deficiency anemia?

A

Can’t tolerate oral ferrous sulfate
Need rapid replenishment

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9
Q

Adverse effect of iron dextran

A

Severe anaphylaxis

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10
Q

Vitamin B12 deficiency causes _____ anemia

A

Megaloblastic

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11
Q

B12 deficiency can cause ____ damage

A

Neurologic (demyelination)

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12
Q

Treatment for B12 deficiency anemia

A

Cyanocobalamin (vitamin B12)

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13
Q

Oral administration of cyanocobalamin requires ____ to be absorbed

A

Intrinsic factor

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14
Q

Severe B12 anemia requires treatment with ___ and _____

A

Folic acid
RBC/platelet transfusion

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15
Q

Treatment with cyanocobalamin can cause a ___ deficiency

A

K+

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16
Q

Folic acid deficiency is identical to B12 deficiency except ____

A

Does not affect nervous system

17
Q

Folic acid is inactive and requires ____ for activation

A

Vitamin B12

18
Q

Erythropoietin drug

A

Epoetin alfa

19
Q

Epoetin alfa requires ___, _____, and _____ to stimulate bone marrow

A

Iron
B12
Folate

20
Q

Adverse effects of epoetin alfa

A

Hypertension and CV events (due to increase in hematocrit)

21
Q

Myeloid growth factor drug

A

Filgrastim

22
Q

Filgrastim stimulates what type of WBC?

A

Neutrophils

23
Q

Indications for filgrastim

A

Reduce risk of infection in immunosuppressed
Neutropenia

24
Q

Adverse effect of filgrastim

A

Bone pain/ache

25
Q

Oprelvekin is a drug version of ____

A

Interleukin-11

26
Q

Function of oprelvekin

A

Thrombopoietic growth factor
Stimulates maturation of megakaryocytes to increase platelets

UNMC PA Pharmacology (23 decks)

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