Hematopoietics Flashcards
Oral treatment for iron deficiency anemia
Ferrous sulfate
How long is anemia treatment with ferrous sulfate?
1-2 months
Prophylactic ferrous sulfate is given to ____ and ____
Pregnant people
People with menorrhagia
Main side effect of ferrous sulfate
GI upset
Treatment for iron toxicity
Deferoxamine (DFO)
Ferrous sulfate drug interactions
Antacids reduce absorption
Reduces tetracycline absorption
IM/IV treatment for iron deficiency anemia
Iron dextran
When is iron dextran given for iron deficiency anemia?
Can’t tolerate oral ferrous sulfate
Need rapid replenishment
Adverse effect of iron dextran
Severe anaphylaxis
Vitamin B12 deficiency causes _____ anemia
Megaloblastic
B12 deficiency can cause ____ damage
Neurologic (demyelination)
Treatment for B12 deficiency anemia
Cyanocobalamin (vitamin B12)
Oral administration of cyanocobalamin requires ____ to be absorbed
Intrinsic factor
Severe B12 anemia requires treatment with ___ and _____
Folic acid
RBC/platelet transfusion
Treatment with cyanocobalamin can cause a ___ deficiency
K+
Folic acid deficiency is identical to B12 deficiency except ____
Does not affect nervous system
Folic acid is inactive and requires ____ for activation
Vitamin B12
Erythropoietin drug
Epoetin alfa
Epoetin alfa requires ___, _____, and _____ to stimulate bone marrow
Iron
B12
Folate
Adverse effects of epoetin alfa
Hypertension and CV events (due to increase in hematocrit)
Myeloid growth factor drug
Filgrastim
Filgrastim stimulates what type of WBC?
Neutrophils
Indications for filgrastim
Reduce risk of infection in immunosuppressed
Neutropenia
Adverse effect of filgrastim
Bone pain/ache
Oprelvekin is a drug version of ____
Interleukin-11
Function of oprelvekin
Thrombopoietic growth factor
Stimulates maturation of megakaryocytes to increase platelets
