Thyroid

Question 1

Main difference between thyroxine(T4) and triiodothyronine(T3)

Answer 1

T3 only has three iodines whole T4 has three iodines. T4 is produced more but T3 is 10 times more potent

Question 2

Difference between non toxic and toxic goiter

Answer 2

Non toxic: linked to enlargement of the thyroid gland due to hypothyroidism. Toxic: linked to enlargement of thyroid gland due to hyperthyroidism

Question 3

Explain the pathology of Graves’ disease

Answer 3

The igG mimics TSH and binds to its receptor causing an overstimulation and over production of thyroxine leading to hyperthyroidism(toxic goiter)

Question 4

Explain the pathology of hashimoto thyroiditis

Answer 4

The body immune system destroys the thyroid gland leading to hypothyroidism(non toxic goiter)

Question 5

Strengths for levothyroxine

Answer 5

25 mcg, 50 mcg, 75 mcg, 88mcg, 100mcg, 112 mcg, 125 mcg, 137 mcg, 150 mcg, 175 mcg, 200 mcg, 300 mcg

Question 6

Starting dose of levothyroxine for normal adults

Answer 6

Max of 100 mcg/day

Question 7

Starting dose of elderly patient more than 65

Answer 7

25 to 50 mcg per day

Question 8

Starting dose of levothyroxine for patient with cardiovascular disease

Answer 8

12.5 to 25 mcg per day