Pituitary Flashcards
What lobe of the pituitary is oxytocin and Vasopressin released from
Posterior lobe
What pathway does growth hormone signal through
Jak/stat pathway
What pathway does LH, FSH, and TSH signal through
GPCR
What does growth hormone increase the production of that cause increase in bone growth
Insulin like growth factor
What does SST hormone do
It blocks the GHRH from stimulating the anterior pituitary gland to make Growth hormone
Describe the structure of growth hormone
It is a single chain protein hormone
Describe the structures of TH, FSH, and LH
They are dimeric proteins that all share common alpha chain
What are the catabolic and anabolic effects of growth hormone
Catabolic effects: reduces central adiposity in lipid cells. Anabolic effects: increases lean body mass.
How does growth hormone affects insulin
It reduces insulin sensitivity
What is the recombinant form of human growth hormone(GH) called
Somtotropin or rhGH
What are ocreotide and Lanreotide
Somatostatin analogs
What are recombinant form of IGF-1
Mecasermin
What is pegvisomant
GH receptor antagonist
What are menotropins
Mixture of FSH and LH
What is the recombinant form of HCG called
Choriogonadotropin
What is desmopressin. Explain its affinity
It is a synthetic analog of vasopressin. It is 4000 times much more selective for V2 receptors than V1 which means it will have more anti diuretic effects than vasoconstriction effects
List the counter indications for oxytocin
Fetal stress Abnormal fetal presentation. Cephalopelvic disproportion(the baby head is too big for the birth canal)
