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Therapeutics Exam 3 > Mens Health > Flashcards

Mens Health Flashcards

1
Q

What is the most common type of alopecia

A

Androgenic alopecia

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2
Q

What is the other type of alopecia that is that is auto immune less common and patient have patches of hair

A

Alopecia areata

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3
Q

What type of alopecia causes complete hair loss on scalp and body

A

Alopecia universalis

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4
Q

For drug induced alopecia what drugs can cause it

A

Anabolic steroids and cancer chemotherapy

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5
Q

What is the treatment option for alopecia in men

A

Finasteride or propecia

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6
Q

What are the side effects of Finasteride

A

ED, decreased volume of ejaculation, women of child bearing age should not handle, decreased libido.

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7
Q

How does Finasteride work

A

Block 5 alpha reductase from changing testosterone to DHT

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8
Q

What is the dosing for Finasteride for treating alopecia

A

1 mg by mouth daily. We want low dose cos they use high dose to treat BPH

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9
Q

Mention another treatment for alopecia

A

Minoxidil or rogaine..apply to scalp twice daily

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10
Q

What is the serum concentration levels of testosterone that confirms low testosterone level

A

First test has to be less than 300 ng/dl and a second test of free testosterone being less than 5 ng/dl

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11
Q

What are the counter indications for testosterone replacement therapy

A

Breast cancer. Prostrate cancer. Hematocrit greater than 50 percent Recent or poorly Cardiovascular disease base line PSA greater than 4 ng/ml or PSA greater than 3 ng/ml in men at high risk of prostrate cancer

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12
Q

What disease can contribute to diabetes

A

Diabetes. Hypertension Parkinson’s. Stroke. Low testosterone

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13
Q

What are the physical things that can cause ED

A

Injury on the bicycle. Prostrate surgery and chemotherapy

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14
Q

What are the drugs that can cause ED

A

Antidepressants particularly SSRI’s. Antihypertensive drugs. Estrogens/anti androgens. 5 alpha reductase Inhibitors. Cancer chemotherapy

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15
Q

What unhealthy lifestyles can cause ED

A

Excessive alcohol. Tobacco smoking. Obesity. Inadequate sleep. Stress

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16
Q

Stepwise treatment for Ed

A

Treat or eliminate known causes. Oral PDE-5 inhibitors. Intraurtheral or intracarvenous injection. Combination therapy. Penis prosthesis

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17
Q

What is the first line treatment for ED and what is important about their usage

A

PDE-5 inhibitors. You need to have sexual stimulation for this drugs

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18
Q

What are the two PDE-5 Inhibitors

A

Tadalafil. Sildefanil

19
Q

Counterindications for PDE 5 inhibitors

A

Oral or transdermal Nitrates cos it can cause hypotension. Patients on alpha blockers Patients with severe coronary artery disease. If erection lasts more than 4 hours call your doctor

20
Q

What is the only PDE-5 inhibitor indicated for BPH and list the dosing

A

Tadalafil and the dose are 2.5, 5, 10 and 20 mg

21
Q

What are alprostadil pallets? What makes them better than oral PDE-5 inhibitors

A

They are prostaglandins and their dosage form is a transurtheral suppository. They are better than oral PDE-5 inhibitors cos you don’t need stimulation for them

22
Q

What type of patients can take alprostadil injection

A

Best for patients who fail PDE-5 inhibitors or patients whose source of ED is neurogenic(from the brain)

23
Q

What are the potential side effects of alprostadil injections

A

Risk of priapism(prolonged erect ion) during titration. Penile pain and local irritation, cavernosal plagues

24
Q

Why is trimix not used for ED intracavernosal injection

A

Greater risk of priapism and also aloprostadil injection is more efficacious

25
Q

What drug can be used to treat priapism

A

Phenylpherine

26
Q

What drugs can cause priapism

A

ED drugs, antidepressants, antipsychotics, blood thinners, cocaine and alcohol

27
Q

What is Xiaflex

A

Treats peyronie disease

28
Q

What ethnicity has the highest rate of prostrate cancer

A

Non Hispanic blacks. They have 198.4 per 100,000. 42.8 per 100,000

29
Q

What is the PSA score for a person who does not have prostrate cancer

A

Under 4ng/ml

30
Q

What are the two symptoms of BPH

A

Obstructive and irritative

31
Q

What type of BPH symptoms is the most devastating to the quality of life

A

Irritative

32
Q

What symptoms of irritative BPH makes it bad

A

Nocturia which is 2 or more voids per night

33
Q

Explain obstructive BPH

A

You have residual volume of like 25-30 ml of urine inside of you

34
Q

Rank the severity of BPH based on AUA score from mild to severe

A

Mild : AUA score is less or equal to 7. Moderate: AUA score is 8 to 19. Severe: AUA score is greater or equal to 20

35
Q

What drugs do we wanna avoid for treatment of BPH

A

First general antihistamines like Benadryl. Tricyclic antidepressants

36
Q

When should we not consider a muscarinic antagonist for BPH

A

If the residual volume is greater than 200 no or the max urine flow is lesser than 5 ml per seconds

37
Q

What is the alpha blocker drug used to treat BPH commonly

A

Tamsulosin

38
Q

What are the side effects of alpha blockers

A

Orthostatic hypotension, dizziness, fatigue, headache

39
Q

What is the PDE-5 inhibitor used for BPH and what is the strength

A

Tadalafil 5mg daily

40
Q

What drug must alpha reductase inhibitors be in combo with to treat BPH and why

A

In combination with an alpha antagonist because it takes 6 months for the drug to start working.

41
Q

What are the two drugs for alpha reductase inhibitors for BPH and lost their dose

A

Finasteride 5 mg daily and dutasteride 0.5 mg daily.

42
Q

What makes Dutasteride 0.5 mg better than Finasteride 5mg

A

Finasteride 5mg is high dose so can cause ED but dutasteride is 0.5 mg so low dose can’t cause ED

43
Q

What is the drug and dose of the drug used for alopecia

A

Finasteride 1mg daily.

Therapeutics Exam 3 (13 decks)

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