Menopausal Hormone Replacement Therapy

Question 1

List the absolute counter indications for hormone replacement therapy

Answer 1

1. Unexplained vaginal bleeding. 2. Pregnancy. 3. Breast cancer. 4 endometrial cancer. 5 Active liver disease. 6. Active or history of thromboembolic disorders. 7. Stroke

Question 2

What is the major principle for estrogen mono therapy

Answer 2

Only good for women without uterus

Question 3

When can a woman with an uterus take estrogen monotherapy

Answer 3

If they are taking intravaginal products excluding femring which has a lot of systemic effects

Question 4

Femring vs estring. Which one can a woman with uterus take and not take

Answer 4

Estring: women with uterus can take it. Femring: women with uterus cannot take it

Question 5

Women experiencing what symptoms can take topic vaginal estrogen mono therapy products

Answer 5

Vulvovaginal atrophy

Question 6

What is the guiding principle for progestin use

Answer 6

Women with uterus should take it in addition to estrogen to reduce the risk of endometrial cancer

Question 7

The woman health initiative study shows what for estrogen and progesterone for women with uterus

Answer 7

1. Increased risk of heart attacks. 2. Increase risk of strokes 3. Increase risk of venous thromboembolism. 4. Increased risk of invasive breast cancers

Question 8

What is the result of the WHI study for women with an uterus on estrogen alone therapy

Answer 8

No increased incidence of heart attacks. Increased risks of stroke. Increased risks of venous thromboembolism.

Question 9

What is peculiar about women less than 60 years within 10 years if menopause with estrogen mono-therapy

Answer 9

They have no risk of getting coronary heart disease, stroke, and breast cancer

Question 10

What progestin offers the best for endometrial protection

Answer 10

Micronized progestin with the brand name prometrium

Question 11

What is the only estrogen and SERM drug for post menopausal woman

Answer 11

Duavee

Question 12

What are the risks associated with duavee

Answer 12

VTE, DVT, strokes

Question 13

What is the only drug prescribed for bio-identical hormone replacement

Answer 13

Bijuva which contains a mince inside progestin

Question 14

What is the drug for estrogen and progestin intermittent combined

Answer 14

Prefest

Question 15

Women with moderate to severe dyspareunia can use what

Answer 15

Ospemifene( osphena) and prasterone(intrarosa)

Question 16

What is the black box warning for ospemifene

Answer 16

Endometrial cancer. Stroke. VTE or thromboembolism

Question 17

Can a woman with hot flashes take ospemifene

Answer 17

No because the side effect of ospemifene is hot flashes

Question 18

What SERM drug is best for moderate to severe dyspareunia(painful sex) and why

Answer 18

Prasterone( intrarosa) because ur doesn’t have black box warning for VTE, stroke and endometrial cancer

Question 19

What are the counter indications for intrarosa

Answer 19

Breast cancer and undiagnosed vaginal bleeding