Thromboses

Question 1

What component of the haemostatic system is incorporated in the formation of a venous thrombosis?

Answer 1

Coagulation cascade, forming a fibrin rich clot

Question 2

What component of the haemostatic system is incorporated in the formation of a arterial thrombosis?

Answer 2

Platelet activation, forming a platelet rich clot

Question 3

Describe the pathogenesis of atherosclerosis

Answer 3

1) Damage to the endothelium invokes the recruitment of “foamy” macrophages
2) These are rich in cholesterol and result in the formation of atherosclerotic plaques

Question 4

Which group of drugs inhibit the aggregation of platelets?

Answer 4

GPIIB/IIIA inhibitors (e.g. abciximab)

Question 5

When should anti-platelets be stopped prior to elective operations?

Answer 5

7 days pre-surgery

Question 6

What is the chief cause of inherited thrombophilia?

Answer 6

Factor V leiden

Question 7

What clotting factors are affected by protein C & S deficiency?

Answer 7

V and VIII