Bleeding Disorders Flashcards
1
Q
What is involved in primary and secondary homeostasis respectively?
A
Platelet plug and fibrin clot
2
Q
What is DIC?
A
Widespread, excessive and inappropriate activation of the haemostat system from the release of procoagulants into the circulation resulting in the consumption of clotting factors and platelets.
3
Q
State 3 causes of DIC
A
- Sepsis
- Obstetric emergency
- Malignancy
4
Q
What is the commonest inherited bleeding disorder?
A
vWF deficiency
5
Q
What can cause a multiple factor deficiency? (3)
A
- Liver failure
- Vit. K deficiency
- DIC
6
Q
What are 2 possible sources of vitamin K?
A
- Diet (e.g. green leafy vegetables).
- Intestinal bacteria
7
Q
How is primary haemostasis affected by Haemophilia?
A
It is is not affected; only secondary haemostasis is depleted.
8
Q
In haemophilia, what clotting time would be raised?
A
APTT
