Thrombocytopenia

Question 1

loss platelet function + Antibody platelet destruction

Answer 1

Idiopathic thrombocytopenia purpura

Question 2

Childhood ITP is due to?

Answer 2

infection

Adults - serious

Question 3

ITP tx?

Answer 3

ICS, IVIG, Platelets, Splenectory, RhoGam, Rituximab

Question 4

1) low platelets 2) anemia 3)fever 4) CNS 5) renal failure - FAT RN

Answer 4

Thrombotic thrombocytopenia purpura - FAT RN

Question 5

Petechia, hemolyic anemia, HA, AMS

Answer 5

Thrombotic thrombocytopenia purpura

Question 6

Low ADAMTs 13 (Little sissors), Clopidegral can cause

Answer 6

Thrombotic thrombocytopenia purpura and HIV

Question 7

Path of Thrombotic thrombocytopenia purpura

Answer 7

Alot of small local clots - hemolytic anemia, and thrombocytopenia bc platelets are all stuck

Question 8

gross hematuria, and splenomegaly

Answer 8

Thrombotic thrombocytopenia purpura

Question 9

Thrombotic thrombocytopenia purpura tx?

Answer 9

PLASMAPHERISIS, ICS,

No Platelets

Question 10

Kids with renal failure, hemolytic anemia and thrombocytic anemia (No fever, No AMS sxs)

Answer 10

HUS

Question 11

HUS caused from

Answer 11

Ecoli 0157:H7 - shiga toxin

Question 12

shiga toxin path?

Answer 12

endothelial damange - thrombin + firbin + platelets

Question 13

TTP vs HUS

Answer 13

HUS does not wax and wane = always there.

Question 14

HUS diag?

Answer 14

Stool for shiga, Urine for shige - schistocute, more Bili/LDH,

Question 15

HUS tx?

Answer 15

Supportive, if oligouria - antibiotix. NO PLATELETS

Question 16

drop in platelets <50,000 with LMWH is

Answer 16

HIT

Question 17

Heparin works on?

LMWK works on?

Answer 17

Xa and formation of thrombin.

Xa.

Question 18

HIT presents with?

Answer 18

PE, DVT, Adrenal clots = lots of clots, skin necrosis, MIs

Question 19

HIT diag? 3 Ts

Answer 19

Thrombocytopenia, Time (4-14 days), thrombosis

Question 20

HIT tx? LAB

Answer 20

Stop Heparin, no warfarin -

Give Lepi/Arga/Biva direct thrombin inhibitor.

Question 21

Widespread microthombosis? Sepsis, trauma, snake bites

Answer 21

DIC

Question 22

DIC diag?

Answer 22

increase D-dimer, High PT, low fibrinogen

Question 23

DIC tx?

Answer 23

underlying cause + Plateles or LMWH

Question 24

dz with decrease PT/INR?

Answer 24

DIC

Question 25

hemolitic anemia dz?

Answer 25

TTP and HUS

Question 26

Big spleen is only in

Answer 26

TTP

Question 27

Low fibrinogen is only in

Answer 27

DIC

Question 28

What disease gets platelets?

Answer 28

ITP and DIC

Question 29

Does only HIT have clots?

Answer 29

yes

Question 30

TTP gets?

Answer 30

FFP