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hematology > Coagulations > Flashcards

Coagulations Flashcards

1
Q

Thrombin and prothrombin make

A

Fibrinogen

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2
Q

Antithrombin, Protein C & S, are

A

fibrinolytic

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3
Q

Male with fever, lethargy, and has Tonic-clonic seizure, Bulging anterior fontanel, PTT 90 what is this?

A

Hemophilia A

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4
Q

factor 8 deficiency and MC

A

Hemophilia A

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5
Q

Factor 9 or Xmas disease is

A

Hemophilia B

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6
Q

Hemophilia heredity is

A

X-linked recessive

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7
Q

Hemathrosis (knee), GI bleed, Gum bleed is associated with?

A

Hemophilia A

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8
Q

Hemophilia A tx? Hemophilia B tx?

A

Factor 8 + Desmopressin (Increase vWF) + FFP

Factor 9. NO desmopressin.

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9
Q

Deep tissue bleed is?

A

Hemophilia B

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10
Q

Definitive test for Hemophilia ?

A

Factor 8 and 9 testing.

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11
Q

Is factor 8 intrinsic or extrinsic?

A

Intrinsic.

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12
Q

easy bleeding and mucsal bleed, bleeding after minor laceration, epistaxis, heavy menses is?

A

vWF deficiency

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13
Q

MC bleeding disorder, vWF hereditary?

A

Auto dom, Protects F8, allows for platelets to clot

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14
Q

vWF diag?

A

Ristocetin - Gold stnd

Normal Platelet count and Prolonged bleeding time, Low vWF activity

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15
Q

vWF Tx?

A

Desmopressin (DDAVP), Cryopercipitate.

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16
Q

What do you avoid in vWF

A

ASA

17
Q

40 male with many DVTs, clotting problem. MC is?

A

Factor V leiden

18
Q

Low Protein C is associated with?

A

Factor V leiden

19
Q

Factor V leiden diag?

A

Protein C assay

20
Q

Factor V leiden tx?

A

Anticoag - ASA

21
Q

Lots of DVTs and PEs is associated with

A

Factor V leiden

22
Q

PT/INR measures

A

Extrinsic pathway and Common - Prothrombin to thrombin to fibrin

23
Q

aPTT measures

A

Intrinsic factors = 12, 11, 8, 9

24
Q

Extrinsic factor is?

A

Factor 5, 7, 10 - external vessel damage

25
Q

Extrinsic medication?

A

ASA

26
Q

Intrinsic medication?

A

Heparin

27
Q

Prolonged activated partial thromboplastin time (aPTT) are associated with?

A

Hemophilia B

hematology (6 decks)

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