Coagulations Flashcards
Thrombin and prothrombin make
Fibrinogen
Antithrombin, Protein C & S, are
fibrinolytic
Male with fever, lethargy, and has Tonic-clonic seizure, Bulging anterior fontanel, PTT 90 what is this?
Hemophilia A
factor 8 deficiency and MC
Hemophilia A
Factor 9 or Xmas disease is
Hemophilia B
Hemophilia heredity is
X-linked recessive
Hemathrosis (knee), GI bleed, Gum bleed is associated with?
Hemophilia A
Hemophilia A tx? Hemophilia B tx?
Factor 8 + Desmopressin (Increase vWF) + FFP
Factor 9. NO desmopressin.
Deep tissue bleed is?
Hemophilia B
Definitive test for Hemophilia ?
Factor 8 and 9 testing.
Is factor 8 intrinsic or extrinsic?
Intrinsic.
easy bleeding and mucsal bleed, bleeding after minor laceration, epistaxis, heavy menses is?
vWF deficiency
MC bleeding disorder, vWF hereditary?
Auto dom, Protects F8, allows for platelets to clot
vWF diag?
Ristocetin - Gold stnd
Normal Platelet count and Prolonged bleeding time, Low vWF activity
vWF Tx?
Desmopressin (DDAVP), Cryopercipitate.
What do you avoid in vWF
ASA
40 male with many DVTs, clotting problem. MC is?
Factor V leiden
Low Protein C is associated with?
Factor V leiden
Factor V leiden diag?
Protein C assay
Factor V leiden tx?
Anticoag - ASA
Lots of DVTs and PEs is associated with
Factor V leiden
PT/INR measures
Extrinsic pathway and Common - Prothrombin to thrombin to fibrin
aPTT measures
Intrinsic factors = 12, 11, 8, 9
Extrinsic factor is?
Factor 5, 7, 10 - external vessel damage
Extrinsic medication?
ASA
Intrinsic medication?
Heparin
Prolonged activated partial thromboplastin time (aPTT) are associated with?
Hemophilia B
