Things I keep getting wrong Flashcards
What is daclatasvir?
NS5A protease inhibitor.
Alongside ABT-267 and Ledipasvir.
What is ABT-450/R?
NS3/4A protease inhibitor:
Alongside Simeprevir,
Faldaprevir and Asunaprevir .
What is ABT - 333?
NNRTI
What is mefloquine?
Inhibits haem detoxification, used in malaria.
What is ABT-267?
NS5A protease inhibitor alongside daclatasvir and ledipasvir.
What do Simeprevir, Faldaprevir and Asunaprevir all have in common?
All NS3/4A protease inhibitors.
How do oxazolidinones function?
Bind to 23s in 50s subunit decreasing the assembly of the initiation complex.
What residue does aspirin target in COX-1?
SERINE 530
What is ledipasvir?
NS5A protease inhibitor alongside ABT-267 and daclatasvir.
What residue does Aspirin target in COX-2?
SERINE 516
Treatment of RA.
Block the synthesis of MMPs.
Treatment of periodontal disease.
Doxycycline at subtherapeutic antibiotic levels.
What is Zileuton?
Asthma treatment, leukotriene antagonist which inhibits LTB4.
What is marimastat?
Hydroxamic acid peptidomimetic used to block the function MMPs by mimicing the shape of the substrate collagen. Not very selective so Prinomastat was developed to be more selective.
Amiloride
Sodium channel blocker used in CF.
Prevents sodium movement back out of mucus into cells, causing the osmotic gradient to remain: water –> out of cells –> into mucus –> thinner mucus –> easier to clear –> less chronic infections.
Doxycycline at subtherapeutic antibiotic levels.
Treatment of RA.
Block the synthesis of MMPs.
Treatment of periodontal disease.
What is Natalizumab?
Anti alpha4 integrin antibody used in treatment of MS prevent translocation of T cells into brain endothelium.
Methotrexate mechanism of action
- Inhibits folate cycle (dihydrofolate reductase).
- May block the proliferation of EC required for angiogenisis in the synovium.
- Suppresses IL-1 induced IL-6 and hence decreased synovial cell proliferation and decreased RONs.
Methotrexate side effects
Resistance can develop.
Bone marrow suppression and GIT damage.
How does sulfasalazine work?
Changes biochemistry of macrophages to produce anti-inflammatory cytokines.
Can be used to treat RA and IBD.
How does penicillamine work?
In treatment of RA it prevents the maturation of newly synthesised collagen.
Decreases joint swelling, RF and concentration of APP.
How does hydroxychloroquine work in RA?
Inhibits PLA2 to reduce cytokine production.
How does Leflunomide work in the treatment of RA?
Orotate dehydrogenase inhibitor.
Prevents synthesis of pyrimidines, suppresses B cells and autoantibody production.
What is special about carbapenems?
Highly resistant to all BLs (NDM-1 included)
Which RA treatment can lead to a recurrence of TB?
Adalimumab. Used in MTX resistant patients for RA and IBD.
