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III > Things I keep getting wrong > Flashcards

Things I keep getting wrong Flashcards

1
Q

What is daclatasvir?

A

NS5A protease inhibitor.

Alongside ABT-267 and Ledipasvir.

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2
Q

What is ABT-450/R?

A

NS3/4A protease inhibitor:
Alongside Simeprevir,
Faldaprevir and Asunaprevir .

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3
Q

What is ABT - 333?

A

NNRTI

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4
Q

What is mefloquine?

A

Inhibits haem detoxification, used in malaria.

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5
Q

What is ABT-267?

A

NS5A protease inhibitor alongside daclatasvir and ledipasvir.

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6
Q

What do Simeprevir, Faldaprevir and Asunaprevir all have in common?

A

All NS3/4A protease inhibitors.

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7
Q

How do oxazolidinones function?

A

Bind to 23s in 50s subunit decreasing the assembly of the initiation complex.

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8
Q

What residue does aspirin target in COX-1?

A

SERINE 530

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9
Q

What is ledipasvir?

A

NS5A protease inhibitor alongside ABT-267 and daclatasvir.

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10
Q

What residue does Aspirin target in COX-2?

A

SERINE 516

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11
Q

Treatment of RA.
Block the synthesis of MMPs.
Treatment of periodontal disease.

A

Doxycycline at subtherapeutic antibiotic levels.

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12
Q

What is Zileuton?

A

Asthma treatment, leukotriene antagonist which inhibits LTB4.

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13
Q

What is marimastat?

A

Hydroxamic acid peptidomimetic used to block the function MMPs by mimicing the shape of the substrate collagen. Not very selective so Prinomastat was developed to be more selective.

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14
Q

Amiloride

A

Sodium channel blocker used in CF.
Prevents sodium movement back out of mucus into cells, causing the osmotic gradient to remain: water –> out of cells –> into mucus –> thinner mucus –> easier to clear –> less chronic infections.

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15
Q

Doxycycline at subtherapeutic antibiotic levels.

A

Treatment of RA.
Block the synthesis of MMPs.
Treatment of periodontal disease.

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16
Q

What is Natalizumab?

A

Anti alpha4 integrin antibody used in treatment of MS prevent translocation of T cells into brain endothelium.

17
Q

Methotrexate mechanism of action

A
  1. Inhibits folate cycle (dihydrofolate reductase).
  2. May block the proliferation of EC required for angiogenisis in the synovium.
  3. Suppresses IL-1 induced IL-6 and hence decreased synovial cell proliferation and decreased RONs.
18
Q

Methotrexate side effects

A

Resistance can develop.

Bone marrow suppression and GIT damage.

19
Q

How does sulfasalazine work?

A

Changes biochemistry of macrophages to produce anti-inflammatory cytokines.
Can be used to treat RA and IBD.

20
Q

How does penicillamine work?

A

In treatment of RA it prevents the maturation of newly synthesised collagen.
Decreases joint swelling, RF and concentration of APP.

21
Q

How does hydroxychloroquine work in RA?

A

Inhibits PLA2 to reduce cytokine production.

22
Q

How does Leflunomide work in the treatment of RA?

A

Orotate dehydrogenase inhibitor.

Prevents synthesis of pyrimidines, suppresses B cells and autoantibody production.

23
Q

What is special about carbapenems?

A

Highly resistant to all BLs (NDM-1 included)

24
Q

Which RA treatment can lead to a recurrence of TB?

A

Adalimumab. Used in MTX resistant patients for RA and IBD.

25
Q

What is Enlimomab?

A

Anti-ICAM

Blocked cellular adhesion molecule so T-cell migration decreased and so did levels of IL-6.

26
Q

What is lopinavir?

A

Protease inhibitor used in treatment of HIV.

Prevents maturation of GAG and POL polyproteins.

27
Q

Gonoorhoea

A

The causative organism is the Gram-negative Neisseria gonorrhoea.
Female patients with gonorrhoea may be asymptomatic.
There is little evidence of infection on the external genitalia.
Uncomplicated gonorrhoea can typically be treated with ciprofloxacin.

28
Q

Staphylococcal skin infections may be treated with

A

flucloxacillin

29
Q

Patients who have Staphylococcus aureus septicaemia would typically be tested for endocarditis by

A

echocardiography

30
Q

Rapid travel across many time zones can pre-dispose travellers to upset stomachs.

A

True

31
Q

It is preferable to eat fruit which can be peeled.

A

True

32
Q

Uncomplicated gonorrhoea can typically be treated with

A

ciprofloxacin.

33
Q

Traveller’s diarrhoea’ is typically caused by strains of Escherichia coli.

A

True

III (24 decks)

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