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Things I keep getting wrong 2 Flashcards

1
Q

Histamine, effect on vascular permeability:

A

Increased

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2
Q

LTD4

A

Bronchoconstriction

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3
Q

Measurement of NSAID selectivity for COX-2

A

Monocyte PGE2 production

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4
Q

H1 receptor is coupled to what?

A

GQ coupled.
PLC linked so Ca2+ increase
Vasodialtory effects on arterioles via NO2
Increased vascular permeability via endothelial contractions and odema formation.
Neuropeptide release: CGRP SP.

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5
Q

TXA2 is mostly produced by

A

PLatelets

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6
Q

ADA is created from PLs how?

A

Action of PLA2

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7
Q

LKs are produced from ADA how?

A

Lipoxygenases

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8
Q

PGI3 has what effect on aggregation?

A

potent anti

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9
Q

What is lipocortin?

A

An endogenous PLA2 inhibitor, so lowers levels of ADA and thus eicosanoids etc.

It is induced by glucocorticoids and can be exploited in anti-leukotriene therapy.

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10
Q

The H1 receptor is PLC linked meaning:

A

GQ coupled.
PLC linked so Ca2+ increase
Vasodialtory effects on arterioles via NO2
Increased vascular permeability via endothelial contractions and odema formation.
Neuropeptide release: CGRP SP.

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11
Q

C3a + C5a , effect on vascular permeability:

A

Increased

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12
Q

What type of drug is zafirlukast?

A

Anti-LTC4

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13
Q

TXA2 has what effect on aggregation?

A

weak pro

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14
Q

Neuropeptide release occurs from stimulation of which H receptor?

A

H1
GQ coupled.
PLC linked so Ca2+ increase
Vasodialtory effects on arterioles via NO2
Increased vascular permeability via endothelial contractions and odema formation.
Neuropeptide release: CGRP SP.

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15
Q

Which H receptor is Gs coupled?

A

H2.
Ac –> increased cAMP
Gastric acid secretion
Vascualr smooth muscle relaxation

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16
Q

Which PG receptor is anti and pro inflammatory?

A

EP2

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17
Q

Bradykinin, effect on vascular permeability:

A

Increased

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18
Q

H1 stimulation results in arteriole dilation how?

A

GQ coupled.
PLC linked so Ca2+ increase
Vasodialtory effects on arterioles via NO2
Increased vascular permeability via endothelial contractions and odema formation.
Neuropeptide release: CGRP SP.

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19
Q

Tritoqualine

A

L-histidine decarboxylase inhibitor.

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20
Q

Which H receptor causes vascular smooth muscle relaxation?

A

H2 Gs coupled
Ac –> increased cAMP
Gastric acid secretion
Vascualr smooth muscle relaxation

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21
Q

PAF, effect on vascular permeability:

A

Increased

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22
Q

Which COX is induced by IL-1, TNFa Growth factors etc?

A

COX2

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23
Q

Anti-LTC4

A

Zafirlukast

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24
Q

LTB4, LTC4, effect on vascular permeability:

A

Increased

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25
Effects of PGE2
Inhibition of gastric acid secretion Increased gastric mucus Increased blood flow
26
Actions of aspirin on COX-1
acetylates SER-530 and interferes with hydrophobic binding pocket.
27
Important residue in COX-2 that isnt Serine?
VAL-523
28
Important residue in COX-1 that is not Serine?
IL-523
29
Vasodilators
``` Histamine Bradykinin NO NP: SP, CGRP PGE2 PGI2 ```
30
Prinzmetal angina
TxA2
31
Measurement of NSAID selectivity occurs how?
``` COX1 = TXA2 from platelets. COX2 = Monocyte PGE2 ```
32
Effects of GCs:
Inhibition of PLA2 Increased Lipocortin, endogenous inhibitor of PLA2 Inhibited COX3 synthesis.
33
Montelukast
LTC4 inhibitor
34
H receptor involved with chemotaxis:
H4
35
Effect of endothelial PGE2 on aggregation:
Inhibited
36
Effect of vascular TXA2 on aggregation
weakly promoted.
37
Tocade
Collagenases
38
Rolipram
Type IV PDE inhibitor. Increases AC, Increases cAMP. Decreases TNF transcription.
39
Leflunomide
Orotate dehydrogenase inhibitor. | B cell depleting due to pyrimidines etc, less antibodies.
40
LTC4 inhibitor
Montelukast
41
Abatacept
CTLA4and Fc of IgGm CD90 + CD86 with CD28 blocked.
42
Decreased transcription can be caused by which PDE IV inhibitor?
Rolipram Type IV PDE inhibitor. Increases AC, Increases cAMP. Decreases TNF transcription.
43
Tocilizumab
Anti IL6R, increases levels of circulation anti inflammatory IL-6.
44
Tofacitinib
JAK3 inhibitor so will block IL2, 3, 5 and 21
45
Chemotaxin LT___
LTB4
46
Bacterial product that is also a chemotaxin
fMLP
47
Delavirdine
NNRTI
48
Lopinavir
Protease inhibitor | GAG and POL
49
NS5A protease inhibitors
Ledipasvir, ABT 267, Daclatasvir
50
Penicllamine
Chelator | Inhibits maturation of newly synthesised collagen.
51
Didanosine
NRTI
52
Aclidinium
Muscarinic antagonist with a fast M2 offtime
53
Active TB treatment
All for two months. | R and I for 4 months after that.
54
Mitogens
Platelet derived growth factor Endothelin Cytokines Histamine
55
ABT-333
NNRTI
56
Ledipasvir
NS5A protease inhibitors
57
Lamivudine
NRTI
58
ABT 267,
NS5A protease inhibitors
59
Zidovudine
NRTI
60
Daclatasvir
NS5A protease inhibitors
61
Nevirapine
NNRTI
62
Latent TB treatment
6-9 months Isoniazid or 3 months of both I and R, 12 weekly doses total.
63
Antibiotics that accumulate in bile
Tetracyclines and macrolides.
64
Efavirenz
NNRTI
65
Monobactams are only active against
G-ve
66
Antibiotic which produces cytotoxics
Metronidazole
67
What has been approved for the prophylaxis of Influenza?
Oseltamivir
68
Aminoglycosides can treat
Gram negative infections
69
Streptomycin is the only aminoglycoside to
Enter the cell
70
Antibiotic limited to 2 weeks of use with blood count monitoring.
Linezolid
71
What type of bacteria are not susceptible to beta lactam antibiotics?
Gram negatives
72
CMV treatment
Ganciclovir
73
Can chloroquine and proguanil be used together in sub-saharan Africa?
NO
74
Are NSAIDs commonly used to treat airway disease?
NO
75
Atypical agents causing pneumonia
M. pneumonia L. pnue Chlamydia
76
Aztreonam
``` Monobactam, Less likely to cause HS, More stable to BLs, Active against only G-ve aerobes, not G+ve or anaerobes. IM or IV for sept or complicated UTIs ```
77
Which is more resistant to BLs? | Monobactams or carbapenems?
Carbapenems.
78
Which antibiotic can only be used topically? Why?
Bacitracin, causes kidney damage when taken systemically.
79
Active against only G-ve aerobes, not G+ve or anaerobes. | IM or IV for sept or complicated UTIs
Aztreonam, a monobactam
80
Most likely cause of an invasive CNS infection
Cryptococcus neoformans
81
Ritixumab is given as:
IV injection/infusion
82
The treatment for meningitis caused by S. pneumoniae is:
14 days of ceftriaxone, 2g IV every 12 hours or 2g Iv every 6Hrs.
83
The treatment for meningitis caused by N. meningitidis is:
This is the most common cause. | 7 days of IV ceftriaxone 2g bd or IV penicillin G or ampicillin with dexamethasone.
84
Heparins do what?
Protective role
85
LTC4 and LTD4 have what effect?
Bronchoconstriction and oedema
86
LTB4 has what effect?
Chemotactic for leukocyte.

III (24 decks)

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