Drug list Flashcards
What is Zileuton and what is it used for?
Used in asthma.
Leukotriene receptor inhibitor which inhibits LTB4.
Monteleukast + Zafirlukast are used to treat what? Why?
Asthma.
Leukotriene receptor antagonists.
What is Sofosbuvir? what does it treat?
Treats HCV.
NS5B RNA polymerase inhibitor.
Shows antiviral activity against all genotypes and barrier to resistances.
What is Simeprivir?
Treatment for HCV.
NS3/4A protease inhibitor.
Faldaprevir is…
Treatment for HCV.
NS3/4A protease inhibitor.
Aunaprevir is…..
Treatment for HCV.
NS3/4A protease inhibitor.
ABT-450/R is what?
Treatment for HCV.
NS3/4A protease inhibitor.
NS5B RNA polymerase inhibitor.
Sofosbuvir:
Treat HCV: Shows antiviral activity against all genotypes and barrier to resistances.
Four inhibitors of the NS3/4A protease of HCV?
Simeprivir
Faldaprevir
Aunaprevir
ABT-450/R
Daclatasvir is….
NS5A protease inhibitor.
Blocks the replication complex formation and assembly.
Only recommended in combination with sofosbuvir +/- ribavirin.
Which anti-HCV medication is recommended in combination with sofosbuvir +/- ribavirin?
Daclatasvir.
NS5A protease inhibitor which blocks the replication complex formation and assembly.
ABT-267
NS5A protease inhibitor
Ledipasvir
NS5A protease inhibitor.
Block the replication complex formation and assembly.
Ribavirin
Nucleoside guanosine analogue that interferes with viral replication, dosing is weight based. Used to treat HCV.
ABT-333
NNRRIs. Act at a number allosteric sites on the RNA replicase enzyme.
What is one non-specific agent/ immunomodulator that an inert glycol has been added to?
PEG-IFN2a.
Used to treat HCV.
A cytokine.
PEGylation can be used to increase the circulating half-life and hide from the immune system.
Three NS5A protease inhibitors:
Daclatasvir.
Ledipasvir.
ABT-267
Imidazoles
Inhibition of CYP450 enzymes. (CYP51A1) the ERG11 gene product.
Prevent effective ergosterol production and damage accrues to cell wall of fungus.
Fluconazole.
nhibition of CYP450 enzymes. (CYP51A1) the ERG11 gene product.
Prevent effective ergosterol production and damage accrues to cell wall of fungus.
Hepatic derangement and QT prolongation.
Orally active.
Terbinafine
Squalene epoxidase inhibitor leading to decreased ergosterol production and changed cell permeability causing lysis.
Avoid in pregnancy, LF and renal toxicity.
Griseofulvin
Only active against dermatophyte infections.
Should take with or after fatty food.
Accumulates in keratinous tissues and prevents tubulin reorganisation needed for fungal cell to move etc.
Sensitivity testing recommended by PHE.
Caspofungin
Echinocandin inhibitor of B-1,3- glucan synthesis in the cell wall.
Anidulafungin
Echinocandin inhibitor of B-1,3- glucan synthesis in the cell wall.
Limited license: invasive candidiasis only.
Can be used in renal/hepatic failure patients.
Amphotericin
Serious fungal infections.
Targets ergosterol in the membrane and will causes creation of pores.
Fungicidal.
IV use only.
Polyenes lead to renal toxicity, electrolyte disturbances, infusion reactions, cardiotoxicity and hepatotoxicity,
Test dose needed, 1mg over 10mins, crash cart on standy.